自然杂志 ›› 2018, Vol. 40 ›› Issue (6): 407-410.doi: 10.3969/j.issn.0253-9608.2018.06.003

• 诺贝尔奖简介 • 上一篇    下一篇

免疫疗法可望治愈肿瘤——解读2018年诺贝尔生理学或医学奖

李丹,王晓霞,李斌   

  1. 上海交通大学医学院 上海市免疫学研究所,上海 200025
  • 收稿日期:2018-12-03 出版日期:2018-12-25 发布日期:2018-12-21
  • 通讯作者: 通信作者,国家杰出青年科学基金获得者,研究方向:调节性T细胞稳定性的动态调控及其临床应用。

Tumors will be cured by immune therapy:A brief introduction to the Nobel Prize in physiology or medicine 2018

LI Dan, WANG Xiaoxia, LI Bin   

  1. Shanghai Institute of Immunology, School of Medicine, Shanghai Jiao Tong University, Shanghai 200025, China
  • Received:2018-12-03 Online:2018-12-25 Published:2018-12-21

摘要:

2018年诺贝尔生理学或医学奖授予了两位科学家,用于表彰其在“抑制负向免疫调节用于肿瘤治疗”方面的发现与贡献。文章回顾了两位科学家所发现的免疫检查点从机制发现到临床应用的发展历程,并详细说明了这些原创性发现对于肿瘤治疗产生的深远影响。

关键词: CTLA-4, PD-1, 免疫疗法

Abstract:

In 2018, the Nobel Prize in physiology or medicine was awarded to James P. Allison and Tasuku Honjo for their discovery of cancer therapy by inhibition of negative immune regulation. This article reviews the process of immune checkpoints discovered by the two scientists from the mechanism to clinical trials. The immune therapy gives human an opportunity to cure tumor.