自然杂志 ›› 2020, Vol. 42 ›› Issue (3): 187-200.doi: 10.3969/j.issn.0253-9608.2020.03.004

• 哈工大百年校庆专刊 • 上一篇    下一篇

面向靶向医疗的微纳米机器人

孙猛猛,谢晖   

  1. 哈尔滨工业大学 机器人技术与系统国家重点实验室,哈尔滨 150080
  • 收稿日期:2020-05-05 出版日期:2020-06-25 发布日期:2020-06-19
  • 作者简介:谢晖,通信作者,国家杰出青年科学基金获得者,研究方向:微纳米机器人技术及应用。

Micro/nanorobots for targeted therapy

SUN Mengmeng, XIE Hui   

  1. State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, Harbin 150080, China
  • Received:2020-05-05 Online:2020-06-25 Published:2020-06-19

摘要: 微纳米机器人指的是尺度在微纳米级别(几纳米至几百微米)的微型机器人,其能够将磁能、光能、声能或其他形式的能量转化为机械运动,具备能完成更高效、更精确局部诊断和靶向治疗的潜在功能,在生物医学领域有广阔的应用前景。文章详细介绍了微纳米机器人的制备方法,阐述了相关驱动手段,总结了其在靶向医疗应用方面的研究进展,并讨论了其在活体应用时面临的挑战以及未来的发展方向。

关键词: 微纳米机器人, 制备方式, 驱动机理, 靶向医疗

Abstract: Micro/nanorobots can be defined as tiny robots with typical dimensions at the micro/nanoscales (several nanometers to hundreds of micrometers), which can convert magnetic, light, ultrasound or other forms of energy into their mechanical motion. The potential capabilities of localized diagnosis and treatment with higher precision and efficiency make the micro/nanorobots a
promising tool for a variety of biomedical applications. This article reviews recent research progress in preparation, driving of the
micro/nanorobots, with a special focus on their preliminary applications for directed drug delivery in vivo. In addition, we discuss the challenges of in vivo applications and future trends.