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Table of Content

    25 April 2019, Volume 41 Issue 2
    Invited Special Paper
    Developing artificial intelligence with a down-to-earth approach
    GUO Yike
    2019, 41(2):  79-84.  doi:10.3969/j.issn.0253-9608.2019.02.001
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    Today, artificial intelligence has been significant progress. The breakthrough development of machine learning has promoted the adaptation of artificial intelligence with a wide range of applications. Artificial intelligence become a new highland for the development of science and technology in the world, and all countries have made strategic investment. At the same time, the development of artificial intelligence has also presented us with a new challenge, introducing new topics in our ethics and social governance. While looking forward to the bright future of artificial intelligence, we must also clearly recognize the limitation of current state-of-the-art in artificial intelligence, especially machine learning. The basic methods and basic ideas are relatively still simple and rough. Today’s artificial intelligence is mainly focusing on the emulation of external function of the human intelligence. The development of artificial intelligence still needs to be continuously progressed in the understanding of the intelligent connotation. This article addresses the approaches for future development of artificial intelligence, especially the direction of machine learning research by emphasising a knowledge support and data driven methodology.

    Progress in industral VOCs control functional materials
    WANG Chenhao, YAN Bingjun, WANG Jirong, NIU-HE Jingying, GAO Guoyu, CHEN Hao, CHENG Lingli, WU Minghong, JIAO Zheng
    2019, 41(2):  85-99.  doi:10.3969/j.issn.0253-9608.2019.02.002
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    Volatile organic compounds (VOCs) is one class of important atmospheric pollutants, which threat to human health even at a low concentration. The control of VOCs emission is a task which brooks no delay. The quality of functional materials is a key part of the whole VOCs emission control process. In this paper, we summarize the latest academic research progress in functional materials applied in adsorption, photocatalysis and catalytic combustion, and provide some guidance for the design and research of VOCs control materials for the future.

    Progress
    Coessential-joint growth technology of large size single crystal diamond
    2019, 41(2):  100-110.  doi:10.3969/j.issn.0253-9608.2019.02.003
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    The technical approach and status of development of synthetic single-crystal diamond (SCD) were introduced with the comparison of several different chemical vapor deposition (CVD) diamond techniques on their advantages and disadvantages.Coessential-joint growth technology, an effective method for breaking through the dimensional limitation and realizing the large size SCD, was focused on Microwave Plasma CVD (MPCVD). Inch sized SCD wafer was achieved. The discussion and analysis were presented on the scientific issues such as lateral growth, interface quality and evolution, as well as the control of 3D structure
    connecting process. In addition, the prospects in the field of advanced applications were forecasted.

    Ageing and homeostasis
    SONG Mengjiao, LIU Meng, HU Qingyuan, WANG Xiaojie, SHEN Yidong
    2019, 41(2):  111-118.  doi:10.3969/j.issn.0253-9608.2019.02.004
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    Ageing, as an inevitable stage of life, is always in the focus of biology. Since dietary restriction was identified to extend life span in rats in 1930s, various model organisms have been used to explore the phenotypes and mechanisms of ageing. Ageingrelated diseases, such as neurodegenerative diseases, became the major risk factor of health. The research on ageing is more and more important to individuals’ health and the sustainable development of the ageing society. Herein, we briefly summarize the molecular mechanisms and interference of ageing from the viewpoint of degenerating homeostasis, which is widely considered as the cause and phenotype of ageing.

    Percolation theory, method, progress, and existing problems
    ZHANG Liying, REN Jingli
    2019, 41(2):  119-131.  doi:10.3969/j.issn.0253-9608.2019.02.005
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    Percolation theory is an extensive mathematical model abstracted from random diffusion phenomena (such as the process of fluid particles gradually diffusing through porous media and forming random paths)﹒ It mainly focuses on the evolution law, behavior characteristics and various critical phenomena during the formation process of random geometric structures in disordered systems﹒Percolation is an important branch of mathematics, which involves Graph theory, statistical physics, stochastic processes, topology, geometry, algebra and dynamic systems analysis etc﹒ Percolation theory is not only of great theoretical significance but also has a broad application background﹒ It has brought new perspectives and provided new theoretical methods for problems in the fields of
    ecology, physics, material science, infectious diseases, and complex networks, etc﹒ Nowadays, percolation is in its critical period﹒ It is the key problems of percolation to determine the critical conditions for percolating transition, and to understand the intricate structure of percolation clusters and their geometric characteristics near the critical point﹒ This paper introduces the main problems, methods and results of percolation theory, and briefly reviews its landmark achievements﹒ Finally, some questions worthy of consideration and research are put forward﹒

    Comprehensive Survey
    Field excursion of the hydrology-climate of Murray Darling Basin in Australia
    NING Like①②,LUO Yong②,JIANG Tong③,SU Buda④,XU Ying④,CHEN Jie⑤,
    2019, 41(2):  132-136.  doi:10.3969/j.issn.0253-9608.2019.02.006
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    At the invitation of the Commonwealth Scientific and Industrial Research Organisation, a scientific research delegation organized by Tsinghua University went to the Murray Darling Basin in Australia for a one-week field excursion in April 2018. The delegation went upstream from the mouth of the Murray Darling River to Canberra, and conducted in-depth exchanges with Australian counterparts and farmers. The research status of hydrology-climate, risk management of extreme hydrological events, water management systems, and climate change mitigation are further understood. The results are beneficial to understand the atmosphericland surface-hydrological interaction mechanism of multi-temporal scale and its impact on natural forcing and human activities, to uncover the response mechanism of forced and underlying human activities, to reveal the dynamic evolution of energy-water cycle and the causes of extreme hydrological events in the global climate system, to construct a risk management system for extreme hydrological events in the context of global warming, and to propose China’s adaptive countermeasures.

    Science Review
    Portraits
    A new era of immune normalization cancer immunotherapy initiated by CHEN Lieping
    SUN Jingwei, WANG Jun
    2019, 41(2):  144-150.  doi:10.3969/j.issn.0253-9608.2019.02.008
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    Cancer immunotherapy by antibody blockade of immune evasion mechanisms, especially the PD-1/B7-H1(PD-L1) pathway, elicits strong antitumor immunity and shows prolonged and ground-breaking therapeutic effect in various types of human cancers, which is awarded Nobel prize in Physiology or Medicine in 2018. Dr. Chen Lieping who first cloned B7-H1 in 1999 and clarified its critical function in cancer immunity, laid the foundation for this field and the success application of PD pathway in the treatment of cancer. This article reviews the major contributions of Dr. Chen along the timeline of the progress of cancer immunotherapy, highlighting the distinct features of PD pathway and discussing the prospects of the field.

    Science Focus
    Truth only comes from the solid experimental data: Chinese scientists successfully clear off the long controversial suspicions in off-target of gene editing
    HE Dongming
    2019, 41(2):  151-156.  doi:10.3969/j.issn.0253-9608.2019.02.009
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    Genome editing is a high promising biotech for correcting pathogenic mutations and trial improvement,and is widely used in basic and applicable researches. However, the true off-target rate of this technology has long been controversial, which has seriously hindered its development. In March 2019, two scientific reports led by Yang Hui and Gao Caixia, respectively, finally revealed the mystery of off-target, and both studies published in Science. Both of the mouse and rice studies consistently found that the cytosine editor causes severe point mutations, while the adenine editor and the classic CRISPR/Cas9 have no significant off-target effects. This article reviews why the off-target suspects has been long remain unsolved, andhow the latest researches achieve in precise off-target detection and
    obtain very rigorous data and conclusions, which base on constructing rigorous experimental controls. At the same time, it was discussed here that humans must be cautious in conducting human clinical trials before the risks are truly eliminated.

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