帕金森病是第二大神经退行性疾病，目前发病机制尚不明确且无法治愈。抗增殖蛋白2参与维持线粒体形态和功能的稳定、凋亡等多种生物学进程。文章主要阐述抗增殖蛋白2与帕金森病之间的联系，进而探讨抗增殖蛋白2在帕金森病发病 线粒体机制中的作用。

Parkinson’s disease, the second largest neurodegenerative disease, cannot be cured. Its pathogenesis is currently unclear. Prohibitin 2 participates in various biological processes such as apoptosis and maintaining the stability of mitochondrial morphology and function. The present review focuses on the relationship between prohibitin 2 and Parkinson’s disease, and then explores the role of prohibitin 2 in the mechanism of mitochondria in the pathogenesis of Parkinson’s disease.