2026年，Eon Systems发布一项非同行评议的数字果蝇演示，将FlyWire连接组模型与虚拟身体仿真相结合，引发关于全脑仿真边界的讨论。该数字果蝇系统通过连接组图谱来约束神经活动，并与虚拟身体耦合实现梳理身体、觅食等行为控制。这类演示虽然仍处于早期探索阶段，但它提示数字脑研究正在从静态连接图谱，逐步走向可运行、可交互和可验证的动态神经仿真系统。随着神经科学、类脑智能与计算技术的飞速发展，数字脑研究逐渐成为全球科技竞争的新高地。本文以从线虫到果蝇的数字脑模拟技术演化为线索，探讨了数字脑的技术路线、科学意义、全球局势以及局限性。通过回顾线虫全脑仿真的开创性尝试、果蝇全脑仿真从结构到功能的飞跃，揭示数字脑技术在智能涌现机制中的关键作用。希望本文可以为相关研究提供参考与启示。

In 2026, Eon Systems released a non-peer-reviewed demonstration of a digital fruit fly (Drosophila melanogaster),
combining the FlyWire connectome model with a virtual body simulation, which sparked discussions on the boundaries of wholebrain emulation. By using the connectome as a structural constraint on neural activity and coupling it with a virtual body, the system demonstrated behavior control such as grooming and foraging. While such demonstrations remain in the early stages of exploration,they suggest  that digital brain research is gradually shifting from static connectome maps towards dynamic, operational, interactive, and verifiable neural simulation systems. With the rapid development of neuroscience, brain-inspired intelligence, and computing technologies, digital brain research has become a new frontier in global technological competition. This paper traces the evolution of digital brain simulation techniques from Caenorhabditis elegans to D. melanogaster, exploring the technical routes, scientific
significance, global landscape, and limitations of digital brain research. By reviewing the pioneering attempts at whole-brain emulation of C. elegans and the leap from structure to function in D. melanogaster whole-brain simulation, we reveal the critical role of digital brain technology in the mechanisms of intelligence emergence. This review is expected to provide useful insights for future research on digital brain systems.