Parkinson’s disease, the second largest neurodegenerative disease, cannot be cured. Its pathogenesis is currently unclear. Prohibitin 2 participates in various biological processes such as apoptosis and maintaining the stability of mitochondrial morphology and function. The present review focuses on the relationship between prohibitin 2 and Parkinson’s disease, and then explores the role of prohibitin 2 in the mechanism of mitochondria in the pathogenesis of Parkinson’s disease.