Special Issue for Advanced Immunochemical Studies

Progress on structures of anti-tuberculosis drug targets

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  • ①Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China; ②School of Life
    Science and Technology, ShanghaiTech University, Shanghai 201210, China

Received date: 2021-06-16

  Online published: 2021-10-22

Abstract

Tuberculosis, mainly caused by the pathogenic bacteria Mycobacterium tuberculosis , is an infectious disease that seriously threats human life and health. The even worse situation currently is the drug resistance problem. Thus, new anti-tuberculosis drugs are urgently needed. Studies on the structures of anti-tuberculosis drug targets will assist in drug development. This paper summarizes
the latest research progress on structures of the crucial drug targets involved in the two important physiology processes of cell wall biosynthesis and energy metabolism in Mycobacterium tuberculosis , and also analyzes the structure-function relation of these
membrane proteins and their complexes as well as the precise mode of actions of the known drug molecules on these targets, and the important value for the design of new anti-tuberculosis drugs.

Cite this article

CHEN Xiaobo , LI Jun . Progress on structures of anti-tuberculosis drug targets[J]. Chinese Journal of Nature, 2021 , 43(5) : 335 -342 . DOI: 10.3969/j.issn.0253-9608.2021.05.003

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