As an indispensable part of the wearable electronic device system, the flexible intelligent sensor stands at an essential frontier currently, which is promising in the application of personal health surveillance, man-machine interaction, and artificial electronic skin. The research status of flexible intelligent sensors with various types is briefly reviewed, and the key technical parameters of flexible sensors are summarized in this article. The challenges and new methods of large-scale manufacturing of flexible sensors are expounded and analyzed. Finally, the development trend of flexible sensors in the future is prospected.