Review Article

Viral genome packaging motor

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  • ①Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325001, Zhejiang Province, China; ②Oujiang Lab,  Wenzhou 325000, Zhejiang Province, China

Received date: 2022-09-28

  Online published: 2023-02-06

Abstract

The virus cannot replicate itself until it has infected host cell and irritated relative biomotorsto exhaust latter’s ATP. The packaging of the viral genome, however, is the key step of viral replication. The dsDNA or dsRNA virus has to utilize hydrolysis energy of ATP by a biomotor to inject its nascent disordered genome into the preformed capsid to form a crystal-like structure before it completes replication. Here, we briefly introduce the structure, function and working mechanism of the packaging motor, and infer that its mechanochemical coupling is irreversible from the perspective of efficiency.

Cite this article

DAI Liqiang, SHU Yaogen . Viral genome packaging motor[J]. Chinese Journal of Nature, 2023 , 45(1) : 17 -21 . DOI: 10.3969/j.issn.0253-9608.2023.01.002

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