Mercury (Hg) is a global pollutant because the atmospheric Hg can be transported globally and deposited into aquatic and terrestrial environments even in remote regions. Atmospheric particulate-bound mercury (PBM) plays a critical role in Hg deposition on the Tibetan Plateau. The importance of atmospheric PBM in Hg biogeochemical cycling on the Tibetan Plateau and research process was introduced in this article. Supported by the second Tibetan Plateau scientific expedition and research program, transboundary transport of atmospheric PBM and its potential environmental effect will be profoundly studied. These results are expected to provide valuable and fundamental scientific basis for the regional environmental protection.