Biological materials are specially designed and manufactured for the interaction with biological system, applied in medicine, tissue engineering and regenerative medicine. These biomaterials possess specific physical, chemical, and biological properties with excellent biocompatibility. In the field of regenerative medicine, artificial intelligence (AI) is emerging as a new frontier by injecting precision-driven momentum into material development, becoming a pivotal force in advancing precision healthcare. This review systematically explores the role of AI throughout the entire lifecycle of biomaterial design, degradation, and application.