Ageing, as an inevitable stage of life, is always in the focus of biology. Since dietary restriction was identified to extend life span in rats in 1930s, various model organisms have been used to explore the phenotypes and mechanisms of ageing. Ageingrelated diseases, such as neurodegenerative diseases, became the major risk factor of health. The research on ageing is more and more important to individuals’ health and the sustainable development of the ageing society. Herein, we briefly summarize the molecular mechanisms and interference of ageing from the viewpoint of degenerating homeostasis, which is widely considered as the cause and phenotype of ageing.