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Table of Content

    25 April 2022, Volume 44 Issue 2
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    SPECIAL ISSUE FOR BIOMEDICINE
    Research progress of transcription factor BACH1
    HE Yunquan, GUO Jieyu, WEI Xiangxiang, MENG Dan
    2022, 44(2):  79-86.  doi:10.3969/j.issn.0253-9608.2022.02.001
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    The transcription factor BTB and CNC homology 1 (BACH1) is expressed widely in most mammalian tissues, functioning
    as a key regulator in oxidative stress-response, cell cycle, heme homeostasis, inflammation, and immunity. In recent years, great
    progress has been made in the research of BACH1 in cardiovascular diseases, stem cell pluripotency maintenance and cancer.
    Genome-wide association studies (GWAS) suggest a closely connection between BACH1 and cardiovascular diseases. BACH1 is
    involved in the occurrence and development of various cardiovascular diseases, such as ischemic angiogenesis, hypertension and
    atherosclerosis. BACH1 is a critical factor of stem-cell identity maintenance and mesendodermal differentiation. BACH1 promotes
    tumor proliferation and metastasis by reprogramming tumor metabolism and altering epithelial-mesenchymal transformation
    phenotypes. While BACH1 may inhibit tumor growth by controlling ferroptosis, thus playing a dual role in tumors. BACH1 has the
    ability to regulate its own expression, and function as both a transcriptional activator and a transcriptional repressor on downstream
    target gene. Different cell phenotypes and states, in vivo environment, and recruitment of coregulatory factors all associate with
    BACH1 transcription. The research progress of BACH1 is summarized as follows.
    Skin wound healing: process and molecular mechanisms
    WANG Juan, LI Xiaojie, DOU Hanyu, DING Xiaolei
    2022, 44(2):  87-95.  doi:10.3969/j.issn.0253-9608.2022.02.002
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    Effective tissue repair is essential for the survival of all multicellular organism. Skin plays a vital role in protecting body from harsh external environments. Upon injury, skin wound heals by a dynamic biological process that involves complex interaction of multiple cell lineages, extracellular matrix molecules and soluble mediators. The compromised or aberrant tissue repair response can lead to unhealing wounds, scarring and even malignancy conversion. In this review, we highlight current concepts in cutaneous wound healing and propose the central mechanisms that regulate wound healing.
    Changes in hematopoietic system after myocardial infarction
    LYU Huizhen , AI Ding
    2022, 44(2):  96-102.  doi:10.3969/j.issn.0253-9608.2022.02.003
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    Acute myocardial infarction (AMI) is the myocardial necrosis caused by coronary artery acute and persistent ischemia and hypoxia. The mobilization and differentiation of hematopoietic stem progenitor cells in bone marrow and extramedullary hematopoietic organs are enhanced after myocardial infarction, which plays an important role in the cardiac acute inflammation and cardiac function repair at the injured tissues to study the specific molecular mechanism will provide more opportunities for clinical
    treatment of myocardial infarction. This paper mainly summarizes the research progress of changes in hematopoietic system after
    myocardial infarction.
    Pathogenic mechanism, prevention and treatment of doxorubicin-induced cardiotoxicity
    WANG Qingwei, DING Rongjing
    2022, 44(2):  103-108.  doi:10.3969/j.issn.0253-9608.2022.02.004
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    Doxorubicin can be used to treat a variety of malignant tumors, but its wide clinical application is limited by doxorubicin-induced cardiotoxicity. The pathogenic mechanism of doxorubicin-induced cardiotoxicity remains unclear, and the available evidence
    for prevention and treatment is still insufficient. This article reviews the pathogenic mechanisms, prevention and treatment of
    doxorubicin-induced cardiotoxicity, aiming to provide a more extensive treatment idea and laboratory evidence for further exploration
    of doxorubicin-induced cardiotoxicity.
    Advances of mitochondrial transplantation for myocardial ischemia
    CHEN Hang , HU Qinfeng , LIN Li , LIU Jianwen , CHEN Kanghui , CHEN Zhaoyang
    2022, 44(2):  109-116.  doi:10.3969/j.issn.0253-9608.2022.02.005
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    Mitochondria are important organelles that provide energy to cells and regulate cell signaling and growth. The development  of many diseases is accompanied by abnormal mitochondrial function. Mitochondrial transplantation is a potential therapy for critical  diseases, especially ischemic diseases. From the perspective of mitochondrial transplantation therapy for myocardial ischemia, this article briefly reviews the effectiveness, mechanism and limitations of mitochondrial transplantation aiming to shed new light on the development of mitochondrial transplantation therapy.
    Cardiovascular atherosclerotic events caused by immune checkpoint inhibitors and prevention and treatment strategies of traditional Chinese and western medicine
    LIU Wenjing, ZHANG Xiaoyu, HAN Songjie, DAI Qianqian, SHANG Hongcai
    2022, 44(2):  117-125.  doi:10.3969/j.issn.0253-9608.2022.02.006
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    The survival time of cancer patients is effectively prolonged with the widespread application of immune checkpoint inhibitors in tumor treatment, and subsequently, the cardiotoxicity problems including coronary artery disease, myocardial infarction, and ischemic stroke became increasingly prominent which arouse the attention on cardiovascular atherosclerotic events of scholars
    because of the urgent appearance and poor prognosis. The article systematically described the cardiovascular atherosclerotic events caused by immune checkpoint inhibitor therapy, the risk factors and risk assessment of this cardiotoxicity, the underlying mechanism, and the prevention and treatment strategies of Chinese and western medicine.
    Diagnosis and treatment of chronic heart failure
    SUN Junyi , XUE Ruicong , LIANG Weihao , DONG Yugang , LIU Chen
    2022, 44(2):  126-148.  doi:10.3969/j.issn.0253-9608.2022.02.007
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    Heart failure is the terminal stage of various heart diseases, and its high mortality and re-hospitalization rate are always been a difficulty in treatment. After years of clinical and basic research, the diagnosis and treatment of heart failure have updated
    rapidly. The current national heart failure guidelines have subdivided heart failure into multiple categories, and have specific diagnosis and treatment methods for each category. This review provides a comprehensive introduction to chronic heart failure in terms of epidemiology, etiology and triggers, diagnosis and treatment of heart failure, complications and prognosis management based on the Chinese, American and European heart failure guidelines. It also makes a brief analysis and outlook for existing clinical trials, in order to make more readers understand the disease.
    Progress on the correlation between non-alcoholic fatty liver disease and cardiovascular disease#br#
    TU Yan , YANG Chanjuan , HUANG Ying , LI Shichao , ZENG Qingchun
    2022, 44(2):  149-154.  doi:10.3969/j.issn.0253-9608.2022.02.008
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    Non-alcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver dysfunction and a serious global health problem. NAFLD has been linked with insulin resistance, obesity, and metabolic syndrome, conditions known to be associated to cardiovascular disease (CVD). A large number of publications demonstrated that people with non-alcoholic fatty liver have an increased risk for developing CVDs, which represent the major cause of death under this setting. Accumulating evidence suggested that NAFLD should be not only a risk factor for CVD but also may be actively involved in the pathogenesis of CVD.
    Application of graphene quantum dots in tumor diagnosis and treatment
    LI Hui, NI Pinyue, MIAO Chenlin, GONG Yan, QIAO Wei, CHEN Fuxue, FENG Shini
    2022, 44(2):  155-165.  doi:10.3969/j.issn.0253-9608.2022.02.009
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    There are many shortcomings in the traditional treatment of cancer, which prompts the research direction of tumor treatment to turn to nanotechnology. Nanotechnology can be utilized to develop and prepare nano-sized materials for disease treatment, diagnosis, and imaging agents. Graphene quantum dots, as a carbon-based nanomaterial with both graphene sheet structure and quantum dot luminescence properties, have the advantages of low biological toxicity, high fluorescence quantum generation rate, stable photoluminescence and superior biocompatibility. They are widely applied in different fields such as catalysis, sensing, bioimaging, medical diagnosis and tumor treatment. Therefore, they become a research hotspot in biomedical materials. This article mainly reviews the research progress of graphene quantum dots in drug delivery, photodynamic therapy, photothermal therapy, fluorescence imaging and tracing in combination with their preparation, properties and applications.
    Research on rehabilitation nursing of stroke patients
    ZHANG Lina, LIU Jing, CHEN Song
    2022, 44(2):  166-172.  doi:10.3969/j.issn.0253-9608.2022.02.015
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    Stroke is the most common neurological disease with high incidence, deformity, mortality and recurrence rate. Despite surviving the crisis period, stroke patients will still have physical and mental disorders due to the damage of brain functional areas, which seriously affects the quality of life and prognosis. It is the key point to explore reasonable rehabilitation nursing methods and
    carry out post-stroke rehabilitation nursing for stroke patients. This article focused on the research progress of rehabilitation nursing of stroke patients, comprehensively elaborated the clinical problems and related evaluation methods in rehabilitation nursing of stroke patients, and reviewed the current research advances of rehabilitation nursing, so as to provide positive ideas for the nursing of stroke patients, promote clinical nursing level, and improve the prognosis of stroke patients.
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