The process of finding the function and the
structure of DNA polymerase is introduced. The key events include the
proposition of active center model of the polymerase, the determination of molecular
weight of the polymerase, the dissociation of the polymerase and achievement of
active fragment, the determination of crystal structure of Klenow fragment
binding DNA and of bacteriophage T7DNA replication. Based on the determined
crystal structure, a right hand model was proposed.