自然杂志 ›› 2020, Vol. 42 ›› Issue (2): 102-107.doi: 10.3969/j.issn.0253-9608.2020.02.005

• 专题综述 • 上一篇    下一篇

OPG/RANKL/RANK：联系骨骼系统与免疫系统的纽带

张云云，梁新月，闫建设   

  1. 上海大学 生命科学学院，上海 200444
  • 收稿日期:2019-10-25 出版日期:2020-04-25 发布日期:2020-04-18
  • 作者简介:闫建设，通信作者，研究方向：免疫与骨关节炎。

OPG/RANKL/RANK: A linkage between the skeletal and immune systems

ZHANG Yunyun, LIANG Xinyue, YAN Jianshe   

  1. School of Life Sciences, Shanghai University, Shanghai 200444, China
  • Received:2019-10-25 Online:2020-04-25 Published:2020-04-18

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摘要： 机体的骨组织细胞和免疫细胞相互影响，使骨骼系统与免疫系统间建立起诸多联系。NF-kB受体活化因子配体不仅调控骨骼和免疫器官的发育，而且在骨骼的自身免疫性疾病中起重要作用。文章简要介绍骨骼系统和免疫系统的结构和生物学功能，阐述骨代谢与免疫系统之间的相互调控作用，重点论述骨保护素/核因子kB受体活化因子配体/核因子kB受体活化因子(OPG/RANKL/RANK)系统作为纽带联系骨骼系统与免疫系统的功能。

关键词: OPG/RANKL/RANK, 骨骼系统, 骨代谢, 破骨细胞, 成骨细胞, 免疫系统

Abstract: The comunication between skeletal and immune systems is formed by interaction of skeletal and immune cells. The receptor activator of nuclear factor-κB ligand plays an important role in the development of bone and immune organs, as well as in autoimmune arthritis. Here we briefly introduce the structures and biological functions of the skeletal and immune systems, and
describe the interactions between them with emphasis on the osteoprotegerin/receptor activator of nuclear factor-κB ligand/receptor activator of nuclear factor-κB(OPG/RANKL/RANK), which functions as a linkage between the skeletal and the immune systems.

Key words: OPG/RANKL/RANK, skeletal system, bone metabolism, osteoclast, osteoblast, immune system

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