中文

Chinese Journal of Nature ›› 2018, Vol. 40 ›› Issue (4): 245-252.doi: 10.3969/j.issn.0253-9608.2018.04.003

• Invited Special Paper • Previous Articles     Next Articles

Artificial spermatids derived semi-clone technology: from origin to application

YAN Meng①②, LI Jinsong①②   

  1. ①Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; ②Genome Tagging Project Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
  • Received:2018-06-08 Online:2018-08-25 Published:2018-09-03

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Abstract:

Artificial spermatids, or haploid embryonic stem cells, extend basic biology researches from cell level to a more reliable animal level. As one kind of embryonic stem cells, artificial spermatids keep high pluripotency and possess the ability to proliferate.In the meantime, they also acquire the ability to infuse with oocytes, like mature sperms, which form zygotes and develop into viable semi-clone offsprings. Artificial spermatids derived semi-clone technology accelerates the basic research, and provides a complete solution for single or multiple gene related genetic disorders. We will talk about the origin of artificial spermatids and semi-clone
technology, as well as its latest application in biology and medicine sciences.