Chinese Journal of Nature ›› 2021, Vol. 43 ›› Issue (1): 39-44.doi: 10.3969/j.issn.0253-9608.2021.01.006

• Review Article • Previous Articles     Next Articles

Advances in AAV-mediated gene therapy for hearing loss 

KE Junzi①②, TAN Fangzhi①②, ZHONG Guisheng①②   

  1. ①iHuman Institute, ShanghaiTech University, Shanghai 201210, China; ② School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China
  • Received:2020-10-01 Online:2021-02-25 Published:2021-02-25

Abstract: Hearing loss is one of the common sensory disorders, and there is no non-device means to restore hearing. In recent years, gene therapy for hearing diseases has gradually moved to the forefront of scientific research and clinical practice. Adeno-associated virus(AAV)is the most commonly used gene therapy vector and plays an important role in the gene therapy of hearing diseases. In this paper, the structure and type of natural AAV were briefly reviewed, and the possibility of AAV-mediated gene therapy for hearing loss was discussed with Anc80L65, AAV2.7m8 and AAV-ie as examples, and the future progress of AAV-mediated gene therapy for hearing loss was also discussed.