Abstract: Retinal degeneration is one of the leading causes of visual impairment. Patients gradually lose their visual function. In many cases, blindness is inevitable. The most prevalent retinal degeneration diseases include retinitis pigmentosa, age-related  macular degeneration, diabetic retinopathy, Stargardt macular dystrophy. With the development of gene therapy, stem cell therapy and visual prosthetic material, a surge of clinical trials for retinal degeneration therapies have emerged. In this article, we summarized the characteristics of retinal degeneration, and discussed the latest applications of pharmacotherapy, gene replacement therapy, stem cell therapy, and visual prosthesis in the clinical treatment for retinal degeneration. We hope that this article provides inspiration for future prospects in restoring impaired visual function.