Abstract: Eastern Tethyan oceanic sediments now outcropped in Himalayan mountains preserved important information for understanding the evolution both of the Tethyan Ocean and of Mesozoic paleoclimate and palaeoceanography. Based on the stratigraphic record from Tibetan Himalayas, this paper overviewed the studies of paleoceanographic events (oceanic anoxic events, oceanic red beds and oxic events, Paleocene-Eocene Thermal Maximum) and major geological events (Early Cretaceous magmatic event and Late Cretaceous tectonic uplift event in northern Indian margin, India-Asia initial collision event; Eastern Tethyan seaway closure event). The studies of high-resolution biostratigraphy, short-term paleoclimatic and paleoenvironmental changes should be strengthened in near future.