中文

Chinese Journal of Nature ›› 2024, Vol. 46 ›› Issue (2): 139-149.doi: 10.3969/j.issn.0253-9608.2023.03.009

• Review Article • Previous Articles     Next Articles

The role of protein post-translational modification in bacterial pathogenesis

ZHOU Tao①, YAO Yufeng①②③④⑤ , WANG Danni①   

  1. ①Laboratory of Bacterial Pathogenesis, Shanghai Institute of Immunology, Shanghai Jiao Tong University School of Medicine,
    Shanghai 200025, China; ②Laboratory of Bacterial Pathogenesis, Department of Microbiology and Immunology, Shanghai Jiao
    Tong University School of Medicine, Shanghai 200025, China; ③Department of Infectious Diseases, Ruijin Hospital, Shanghai Jiao
    Tong University School of Medicine, Shanghai 200025, China; ④State Key Laboratory of Microbial Metabolism, and School of Life
    Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200024, China; ⑤Shanghai Key Laboratory of Emergency
    Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai 200025, China
  • Received:2023-03-03 Online:2024-04-25 Published:2024-04-19

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Abstract: Post-translation modifications (PTMs) are considered to have the effect of changing the stability and activity of proteins, which is one of the important steps to regulate the biological function of proteins, and widely exists in eukaryotes and prokaryotes. PTMs plays a crucial role in regulating bacterial life activities, such as metabolism, signal transduction, pathogenic process, and so on. In this review, we summarized the main types and functions of PTMs in bacteria, the regulation mechanism of PTMs in bacterial virulence and adaptability, the way that bacterial effectors regulates host proteins through PTMs, and the new progress of PTMs detection technology. The study of PTMs are of great significance to understand the bacterial pathogenesis and the bacteria-host interactions. Meanwhile, this study can also provide a new target for the development of specific therapeutic drugs.