Chinese Journal of Nature ›› 2012, Vol. 34 ›› Issue (4): 231-240.

• History of Natural Science • Previous Articles     Next Articles

Discovery of Function and Structure of Deoxyribonucleic Acid Polymerase Ⅲ Holoenzyme

 XIANG Yi-he   

  1. Professor, Department of Physics, Tsinghua University, Beijing 100084, China
  • Received:2012-01-03 Revised:2012-02-03 Online:2012-08-25 Published:2012-08-25

Abstract: The process of finding the structure and the function of DNA polymerase Ⅲ holoenzyme are introduced. The key events include that the discovery of DNA polymerase Ⅲ and Ⅲ* , the proposition of DNA polymerase Ⅲ holoenzyme, the separation of holoenzyme subunit, the function of core polymerase, the 3→5 exonuclease activity of ε subunit,the function of β subunit  sliding clamp and γ complex.

Key words: DNA polymerase Ⅲ, DNA polymeraseⅢ*, , Copolymerase Ⅲ*, core polymerase, ε subunit, β subunit sliding clamp, γ complex