中文

Chinese Journal of Nature ›› 2013, Vol. 35 ›› Issue (6): 442-450.

• Review Article • Previous Articles     Next Articles

New drug research and development: small fish, big chance

WU Zhuan-bin①, FEI Jian②   

  1. ①Master Candidate, Shanghai Research Center for Model Organisms, Shanghai 201210, China; ②Professor, Shanghai Research
    Center for Model Organisms, Shanghai 201210, China; School of Life Sciences and Technology, Tongji University, Shanghai 200092,
    China
  • Received:2013-10-09 Revised:2013-11-09 Online:2013-12-25 Published:2013-12-25

PDF

726

Abstract: Taking advantages of small size, rapid and external development, transparent embryo, fecundity, and numerous signal
transduction pathways, morphological and physiological similarities to mammals, zebrafish has emerged as a powerful in vivo
platform for modeling human diseases and large-scale phenotype-based drug screens. Recently, new zebrafish disease models and
screening technologies have been developed. A number of active compounds were identified using zebrafish models that were also
approved in clinical trials. This review surveys the achievements and potential of zebrafish for modeling human diseases and drug
research and development.

Key words:  zebrafish, disease model, drug