Chinese Journal of Nature ›› 2014, Vol. 36 ›› Issue (3): 192-201.

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Progress of long noncoding RNA in cancer

LI Yan-li,ZHANG Shi-meng,WANG Ju,JIN You-xin   

  1. ①Associate Professor, ③Master Candidate, ④Professor, School of Life Sciences, Shanghai University, Shanghai 200444; ②Master Candidate, First School of Clinical Medicine, Nanjing Medical University, Nanjing 210029
  • Online:2014-06-25 Published:2014-06-25

Abstract: Long noncoding RNA (lncRNA) is defined as transcripts longer than 200 nucleotides (nt) with little or no protein-coding capacity. It was found that lncRNA was originated in complicated sources, and played different functions in multiple levels such as epigenetic, transcriptional and post-transcriptional regulation levels. Here we briefly summarize the origin and biological function of lncRNA, and emphatically focus on the progress in cancer biology.