Loading...

Table of Content

    25 October 2021, Volume 43 Issue 6
    Special Issue for Advanced Immunochemical Studies
    Advances in research on tumor immunotherapy
    LI Long , XIE Chengying , ZHENG Mingyue , JIANG Hualiang
    2021, 43(6):  391-399.  doi:10.3969/j.issn.0253-9608.2021.06.001
    Asbtract ( 10965 )   PDF (3359KB) ( 6397 )  
    References | Related Articles | Metrics
    Tumor immunotherapy can control and kill tumor cells by stimulating or restoring the immune system. It is another effective treatment after surgery, radiotherapy, chemotherapy and targeted therapy. A variety of emerging tumor immunotherapies
    are being applied in clinical research and demonstrate the potential of powerful treatment, benefiting from the rapid development
    of multiple-subjects such as immunology and tumor biology. At present, clinical immunotherapeutic strategies for cancer include
    therapeutic monoclonal antibody immunotherapy, immune checkpoint inhibitor therapy, adoptive cell therapy, oncolytic virus therapy, and tumor vaccine. This paper reviews the development of tumor immunotherapy, and analyzes the latest research progress and futureprospects, in order to provide reference for drug research and development in tumor immunotherapy.
    Novel strategies to target EGFR proteins for degradation and their applications in non-small cell lung cancer
    SONG Xiaoling , QU Xiaojuan , QU Siqi , JIANG Biao
    2021, 43(6):  400-407.  doi:10.3969/j.issn.0253-9608.2021.06.002
    Asbtract ( 1795 )   PDF (2358KB) ( 1127 )  
    References | Related Articles | Metrics
    Activating mutations in the kinase domains of EGFR (epidermal growth factor receptor) lead into the occurrence of non-small cell lung cancer. Currently, the standard care for such diseases is to use EGFR-specific tyrosine kinase inhibitor drugs. However,
    drug resistance inevitably occurs after the treatment with these drugs. Novel strategies are needed to solve these issues to extend
    patients survival time. Due to the dependency of EGFR mutant lung cancer on EGFR proteins and the critical roles of EGFR protein
    in drug resistance, targeted degradation of EGFR protein provides a promising strategy to treat such patients. Several novel strategies have been developed lately to target EGFR for degradation in non-small cell lung cancer. The strategies include proteolysis targeting chimeras (PROTACs), lysosome-targeting chimaera (LYTAC) and stapled-peptide. The latest development of these strategies were reviewed and their potential uses in lung cancer treatment were assessed.
    Invited Special Paper
    Impact of solar activity on Earth’s climate 
    XIAO Ziniu
    2021, 43(6):  408-419.  doi:10.3969/j.issn.0253-9608.2021.06.003
    Asbtract ( 5122 )   PDF (4758KB) ( 2923 )  
    References | Related Articles | Metrics
    Solar radiation is the energy source of the Earth system and the fundamental driving force of climate formation and evolution. The variation of solar radiation reaching the Earth is closely related to the Earth’s climate on a long time scale, such as thousands years. But on time scales of hundreds years and less, it is not clear whether solar activity has a significant impact on climate. Solar activity can affect the Earth’s climate in many ways, and the process is extremely complex. The response of climate system to solar forcing is nonlinear, which results in great uncertainty of the influence of solar activity on climate. In this paper, we summarize the recent studies on the effects of solar activity on the Earth’s climate, and discuss the key factors and possible pathways of the effects of solar activity on the Earth’s climate on the interannual and decadal scales, as well as the sensitive areas and key linkages of the climate system in response to solar activity changes.
    Characteristics of flow over a circular cylinder closed to a wall
    LI Jianghua, WANG Bofu, QIU Xiang, ZHOU Quan, LIU Yulu
    2021, 43(6):  420-429.  doi:10.3969/j.issn.0253-9608.2021.06.004
    Asbtract ( 949 )   PDF (5971KB) ( 1677 )  
    References | Related Articles | Metrics
     The flow over a circular cylinder near a wall is a simplified model from many practical engineering applications. There will be complex and abundant multiscale turbulent structures because of the interaction between the wake of a circular cylinder and the wall boundary layer. In this article, the changes in the frequency of vortex shedding, the drag and lift of the cylinder caused by this turbulent structure in engineering with the generation and evolution of this turbulent structure are summarized and analyzed. And some suggestions for further research are put forward.
    Brief Introduction of Nobel Prize
    Contributions of Chinese chemists to asymmetric organocatalysis awarded Nobel Prize in Chemistry 2021
    GAO Wenchao, JIANG Xuefeng
    2021, 43(6):  430-440.  doi:10.3969/j.issn.0253-9608.2021
    Asbtract ( 2623 )   PDF (3572KB) ( 1895 )  
    References | Related Articles | Metrics
     The Nobel Prize in Chemistry 2021 returned to the basis of chemistry—synthetic chemistry, and was awarded to Benjamin List and David W. C. MacMillan for the development of asymmetric organocatalysis. This concept was formed and developed in the beginning of 21st century, and many Chinese chemists had been involved in this area. This paper was dedicated to the Chinese chemists, who contributed much thoughts and breakthrough in the area of organocatalysis in the last two decades.
    2021 Nobel Prize in Physics: A new era of complex systems science  
    FAN Jingfang, JIN Yuliang
    2021, 43(6):  441-450.  doi:10.3969/j.issn.0253-9608.2021.06.006
    Asbtract ( 1678 )   PDF (7162KB) ( 2074 )  
    References | Related Articles | Metrics
    The Nobel Prize in Physics 2021 was awarded to three scientists for groundbreaking contributions to our understanding of complex physical systems. Syukuro Manabe and Klaus Hasselmann shared half of the prize for the physical modelling of Earth’s climate, quantifying variability and reliably predicting global warming. Giorgio Parisi received the other half of the prize for the discovery of the interplay of disorder and fluctuations in physical systems from atomic to planetary scales. In this article, we reviewed their scientific contributions.
    Discovery and research advance of temperature and touch receptors:Understanding of the 2021 Nobel Prize in Physiology or Medicine
    XIE Hengchang, FU Xiaoyu, SHEN Wei
    2021, 43(6):  451-458.  doi:10.3969/j.issn.0253-9608.2021.06.007
    Asbtract ( 4605 )   PDF (2941KB) ( 4111 )  
    References | Related Articles | Metrics
    The 2021 Nobel Prize in Physiology or Medicine is awarded to David Jay Julius and Ardem Patapoutian for their contributions to the discovery of temperature and touch receptors. We review the discovery of the temperature receptor TRPV1 and the touch receptor PIEZOs by the two scientists, and describe the research advance on these receptors and the great potential for drug discovery
    Natural Forum
    Plant diversity in Yunnan province
    ZHOU Zhekun, CHEN Linlin
    2021, 43(6):  459-466.  doi:10.3969/j.issn.0253-9608.2021.06.008
    Asbtract ( 1474 )   PDF (12794KB) ( 851 )  
    References | Related Articles | Metrics
    Yunnan province, which only accounts for 4.1% of Chinese territory area, however, is the most biodiverse province in China. It harbors 19 333 higher plant species, which is more than half of higher plants in China, including 1 906 species of mosses belonging to 499 genera in 126 families, 1 363 species of fern belonging to 193 genera in 61 families, 113 species of gymnosperms belonging to 25 genera in 9 families, and 15 951 species of angiosperms belonging to 2 367 genera in 244 families. In addition to higher plants, there are 1 067 species of lichen belonging to 203 genera in 66 families, and 2 729 species of macro fungi belonging to 599 genera in 124 families distributed in Yunnan. Considering to vegetation diversity, Yunnan is identified with 14 vegetation types, 38 vegetation subtypes, and 474 forms, ranging from tropical rainforests to shrubs in alpine screes. Such high plant diversity of Yunnan attributes to the rich Earth environmental diversity, the varied climate types, and its special geolocation. In recent years, a series of conservation actions has been carried out in Yunnan, such as counting the floral inventory, compiling conservation lists, establishing germplasm resource banks, and saving and protecting plant species with extremely small populations. Thanks to that, the plant diversity of Yunnan has been effectively protected
[an error occurred while processing this directive]