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中文

Table of Content

    18 May 2025, Volume 47 Issue 3
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    SPECIAL ISSUE
    Microscopic mechanism and macroscopic effects of exercise-mediated miRNA in facilitating cardiac repair
    JIANG Jizong, WANG Rui, ZHANG Xinxin, XIAO Junjie
    2025, 47(3):  157-163.  doi:10.3969/j.issn.0253-9608.2025.03.001
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     The awarding of the 2024 Nobel Prize in Physiology or Medicine emphasizes the important role of microRNA (miRNA) in gene regulation. Regular exercise serves as a “natural prescription” for cardiovascular protection and promotes cardiac repair by regulating the miRNA network. In this review, we initially introduce miRNA and summarize the close connection between miRNA and cardiovascular diseases. Finally, we have summarized the multi-dimensional regulatory mechanism and therapeutic potential of exercise-mediated miRNA in cardiac repair, providing a new model for non-drug intervention in cardiovascular diseases.
    Adaptive immunity changes after myocardial ischemic injury
    LIU Shuqin, QIU Yihui, YANG Langxi, BEI Yihua
    2025, 47(3):  164-171.  doi:10.3969/j.issn.0253-9608.2025.03.002
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    Myocardial ischemic injury is a pathological process with an insufficiency of blood supply to the myocardium mainly caused by partial stenosis or complete obstruction of coronary arteries, which may develop heart failure in severe cases. Adaptive immunity participates in the pathophysiological process of myocardial ischemic injury, and plays an important role in myocardial repair after ischemic injury as well. The present review focuses on the functions and mechanisms of the adaptive immunity involving T cells, B cells, natural killer (NK) cells, and dendritic cells (DCs), as well as the cell interactions mediated by adaptive immune cells in myocardial ischemic injury. In depth analysis of the dynamic changes of adaptive immunity in myocardial ischemic injury and the interaction network of different immune cell subpopulations, as well as the development of novel chimeric antigen receptor (CAR) cell therapy, antibody therapy, and personalized immunotherapy strategies, are expected to bring new hope for the treatment of clinical myocardial ischemic injury.
     Advances in biosensing technology targeting life and health
    ZHAO Jing, ZHANG Juan, CHEN Guifang, CAO Ya, LI Genxi
    2025, 47(3):  172-182.  doi:10.3969/j.issn.0253-9608.2025.03.003
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     Early diagnosis of diseases is essential for improving the prognosis of the patients, particularly for those with major chronic diseases, such as cancers, as early and precise diagnosis can significantly enhance the survival rates of the patients and reduce their healthcare burdens. In recent years, the in-depth integration of biosensing technology and DNA nanotechnology has greatly promoted the rapid advancements in the biomedical field, effectively overcoming the limitations of traditional diagnostic methods and enabling the transition of disease diagnosis to more accurate molecular phenotypic analysis. This advancement has substantially improved the sensitivity, specificity, and real-time monitoring capabilities of the biosensing techniques, providing powerful tools for early disease diagnosis and progression monitoring. This paper, taking the work of our team in recent five years as an example, systematically introduces the progress in biosensing techniques focusing on life and health, particularly highlighting the development of the biosensing techniques in the detection of different biomarkers, such as tumor cells, extracellular vesicles, and bacteria. These developments may pave the way to promote the early screening and precise intervention of major chronic diseases.
    Catalytic biomaterials: A toolbox for pancatalytic precision medicine
    XIA Lili, WU Chenyao, FENG Wei, CHEN Yu
    2025, 47(3):  183-189.  doi:10.3969/j.issn.0253-9608.2025.03.004
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      Catalytic biomaterials represent a cutting-edge interdisciplinary research frontier that bridges biomimetic chemistry with advanced materials science. By harnessing the intrinsic catalytic properties of engineered materials and incorporating precisely tunable nanostructures, these systems offer transformative strategies to address the inherent limitations of conventional therapeutic modalities. A key advantage of catalytic biomaterials lies in their finely controlled composition, morphology, and surface chemical functionalities, which collectively enable the targeted modulation of critical biochemical reactions within pathological microenvironments. Such modulation facilitates the localized and sustained generation of bioactive species, thereby enhancing therapeutic specificity and efficacy while simultaneously minimizing systemic toxicity and adverse effects. This review systematically elucidates the fundamental design principles and optimization strategies for constructing catalytic biomaterials, explores their mechanistic pathways in disease modulation, and highlights their translational potential in clinical pancatalytic disease treatments. Furthermore, it identifies and discusses the major scientific and technological challenges that must be addressed to advance the clinical integration of these promising therapeutic platforms.
    A new era in cancer phototherapy: development, mechanisms and applications
    FU Yongbo, XIANG Huijing
    2025, 47(3):  190-195.  doi:10.3969/j.issn.0253-9608.2025.03.005
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    As an emerging treatment technology, phototherapy has attracted widespread attentions in the field of cancer treatment due to its non-invasive, targeted, spatially controllable nature and relatively low toxicity and side effects. There are two main types of phototherapy: photodynamic therapy and photothermal therapy. The article first briefly introduces the development history of phototherapy, and then describes the mechanism of the two types of phototherapy, the classification of photosensitizers and photothermal agents, and the application of combination therapy in cancer treatment. Finally, it lists the main challenges in the development of phototherapy technology. In short, phototherapy shows great potential in cancer treatment. With continuous technological innovation and maturity, phototherapy is expected to become a major milestone in the field of biomedicine.
    Research advances in liquid biopsy for cardiovascular diseases
    YANG Shiyun, NIU Jingsong, CHE Xinran, FENG Chang, ZHU Xiaoli
    2025, 47(3):  196-206.  doi:10.3969/j.issn.0253-9608.2025.03.006
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     Cardiovascular diseases (CVD) remain one of the leading causes of global mortality, while their early diagnosis and real-time monitoring continue to present significant clinical challenges. Liquid biopsy, by virtue of its non-invasiveness, superior sensitivity, and capacity for longitudinal surveillance, provides a new approach for early screening, disease progression monitoring, and precision treatment of CVD. This review systematically summarizes recent advancements in liquid biopsy applications for cardiovascular diseases, methodologically delineating three pivotal biomarker classes: extracellular vesicles (EVs), circulating cell free nucleic acids, and cardiac-specific proteins exemplified by troponin and brain natriuretic peptide (BNP). In terms of detection technology, this review comprehensively evaluates emerging platforms spanning digital PCR, high-throughput sequencing, mass spectrometry, and microfluidic chips, with particular emphasis on the critical value of multi-technology integration strategies to achieve synergistic enhancement in biomarker capture efficiency and analytical precision. Finally, this review discusses the challenges and future prospects of liquid biopsy in clinical applications for cardiovascular diseases.
    Application of image recognition model in wildlife protection
    JI Jingwen, ZHONG Junjie, NIU Bing, CHEN Qin
    2025, 47(3):  207-214.  doi:10.3969/j.issn.0253-9608.2025.03.007
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     As an important branch of artificial intelligence, image recognition model shows great application potential in the field of wildlife protection. This paper first outlines the basic types of image recognition models, and then elaborates the construction process of wildlife image recognition models, including data acquisition, preprocessing, model training and other key steps. Finally, the application scenarios of image recognition model in wildlife protection are discussed. The research shows that the image recognition model can significantly improve the efficiency and accuracy of wildlife conservation, and provide a strong technical support for biodiversity conservation. In the future, with the continuous progress of technology, image recognition models will play a more important role in wildlife protection.
     Application of biological preservation technology in the postharvest field of fruits and vegetables
    WAN Sibao, QIN Zhen, WEI Yunfan, YAN Jiabao, TIAN Xiao, DONG Lianger, GAO Haiyan
    2025, 47(3):  215-222.  doi:10.3969/j.issn.0253-9608.2025.03.008
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     China is the world's largest producer of fruits and vegetables, yet postharvest losses caused by pathogenic microbial infections remain as high as 15% ~ 25%, resulting in significant economic losses and posing serious challenges to food security and sustainable resource utilization. Driven by the “Healthy China” initiative and the “Dual Carbon” goals, the development of green and safe biocontrol preservation technologies is of great significance in reducing reliance on chemical preservatives and promoting the low-carbon transformation of the fruit and vegetable industry. This paper systematically reviews the mechanisms and applications of bio-preservation technologies, including antimicrobial compounds derived from plants and animals, antagonistic microorganisms and their metabolites, and novel enzyme preparations. Furthermore, it discusses the current bottlenecks and potential strategies for industrial-scale implementation. The findings provide theoretical support for key technologies in reducing postharvest losses and establishing a sustainable green supply chain.
     Construction and application of skin organoids
    ZHENG Zongyao, WANG Yalong
    2025, 47(3):  223-232.  doi:10.3969/j.issn.0253-9608.2025.03.009
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     Skin, the largest organ of the human body, is composed of closely adjacent epidermis and dermis, which plays vital roles in human life, including barrier function, thermoregulation, sensation, and immunity. In recent years, with the rapid advancement of organoid research, skin organoids have garnered increasing attentions and have been widely applied. This review systematically summarizes current methodologies for constructing both composite skin organoids and individual skin appendage organoids, encompassing differentiation induction from induced pluripotent stem cells (iPSCs) to self-organization of adult stem cells into organoids. Additionally, it outlines the diverse applications of skin organoids, such as disease modeling, regeneration of tissues and organs, tumor research, and drug efficacy evaluation. In addition to comprehensively evaluating existing constraints in skin organoid development, we present targeted recommendations for technological innovation, establishing a conceptual foundation for advancing this field.
    Applications and challenges of RNA therapy
    CHIN Lai Ka Jerry, SHEN Boyu, ZHENG Yuxuan, JIANG Yiyue, TAO Pengjie, LU Dongchao
    2025, 47(3):  233-238.  doi:10.3969/j.issn.0253-9608.2025.03.010
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    Gene therapy emerged as a promising novel treatment for undruggable diseases. Over the past few years, RNA therapy has emerged as a pivotal subset of gene therapy, with the development of the RNA technology. Here, we summarized the cutting edge investigations of RNA therapy, with a focus on its applications in treating various diseases, the results from clinical trials, and its future prospects. RNA therapy enables the precise regulation of dysfunction or disorder genes. Given the relatively straightforward design and preparation processes of the RNA-based medicines, they can be swiftly developed into novel therapies for diverse diseases. Moreover, RNA molecules offer new avenues for treating complex diseases and are poised to play a crucial role in the realization of precision medicine in the future.
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