关键词: X染色体失活, 长非编码RNA, Xist , 伴性遗传

Abstract:

In female mammals’ body cells, one of the X-chromosomes is inactivated as heterochromatin to balance the expression of X-linked genes in females and males. This is so called X chromosome inactivation, the biological basis of many biological phenomena and diseases. Here, we briefly review the phenomena, the basic knowledge of the X chromosome inactivation and the connections to disease.