免疫检查点抑制剂引起的心血管动脉粥样硬化事件及中西医防治策略

doi:10.3969/j.issn.0253-9608.2022.02.006

自然杂志 ›› 2022, Vol. 44 ›› Issue (2): 117-125.doi: 10.3969/j.issn.0253-9608.2022.02.006

免疫检查点抑制剂引起的心血管动脉粥样硬化事件及中西医防治策略

刘文静，张晓雨，韩松洁，代倩倩，商洪才

北京中医药大学东直门医院，中医内科学教育部和北京市重点实验室，北京 100700

收稿日期:2021-11-22 出版日期:2022-04-25 发布日期:2022-05-05
通讯作者: 商洪才，通信作者，国家杰出青年科学基金获得者，研究方向：中医临床评价方法、心血管疾病中医药防治临床基础研究。

Cardiovascular atherosclerotic events caused by immune checkpoint inhibitors and prevention and treatment strategies of traditional Chinese and western medicine

LIU Wenjing, ZHANG Xiaoyu, HAN Songjie, DAI Qianqian, SHANG Hongcai

Key Laboratory of Chinese Internal Medicine of Ministry of Education, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China

Received:2021-11-22 Online:2022-04-25 Published:2022-05-05

摘要/Abstract

摘要： 随着免疫检查点抑制剂在肿瘤治疗中的广泛应用，癌症患者的生存期得到有效延长，但随之而来的心脏毒性问题日渐凸显，其中冠状动脉疾病、心肌梗死和缺血性卒中等动脉粥样硬化性血管事件因起病急、预后差而引起学者的关注。文章系统阐述了免疫检查点抑制剂治疗引起的心血管动脉粥样硬化事件，产生这种心脏毒性的风险因素及风险评估，以及潜在的发生机制和中西医防治策略。

关键词: 免疫检查点抑制剂, 心脏毒性, 心血管动脉粥样硬化事件

Abstract: The survival time of cancer patients is effectively prolonged with the widespread application of immune checkpoint inhibitors in tumor treatment, and subsequently, the cardiotoxicity problems including coronary artery disease, myocardial infarction, and ischemic stroke became increasingly prominent which arouse the attention on cardiovascular atherosclerotic events of scholars
because of the urgent appearance and poor prognosis. The article systematically described the cardiovascular atherosclerotic events caused by immune checkpoint inhibitor therapy, the risk factors and risk assessment of this cardiotoxicity, the underlying mechanism, and the prevention and treatment strategies of Chinese and western medicine.

刘文静, 张晓雨, 韩松洁, 代倩倩, 商洪才 . 免疫检查点抑制剂引起的心血管动脉粥样硬化事件及中西医防治策略[J]. 自然杂志, 2022, 44(2): 117-125.

LIU Wenjing, ZHANG Xiaoyu, HAN Songjie, DAI Qianqian, SHANG Hongcai. Cardiovascular atherosclerotic events caused by immune checkpoint inhibitors and prevention and treatment strategies of traditional Chinese and western medicine[J]. Chinese Journal of Nature, 2022, 44(2): 117-125.

导出引用管理器 EndNote|Reference Manager|ProCite|BibTeX|RefWorks

链接本文: https://www.nature.shu.edu.cn/CN/10.3969/j.issn.0253-9608.2022.02.006

https://www.nature.shu.edu.cn/CN/Y2022/V44/I2/117

免疫检查点抑制剂引起的心血管动脉粥样硬化事件及中西医防治策略

Cardiovascular atherosclerotic events caused by immune checkpoint inhibitors and prevention and treatment strategies of traditional Chinese and western medicine

PDF

可视化

摘要/Abstract

引用本文

使用本文

相关文章 1

编辑推荐

Metrics

本文评价