自然杂志 ›› 2022, Vol. 44 ›› Issue (3): 231-240.doi: 10.3969/j.issn.0253-9608.2022.03.005

• 科技进展 • 上一篇    下一篇

DNA感受器AIM2在心血管疾病中的研究

陆琳 ，吴诚洁 ，涂均楚，李玉洁，张瑜，李杨欣    

  1. 苏州大学医学院附属第一医院 心血管病研究所，江苏 苏州 215006
  • 收稿日期:2022-04-14 出版日期:2022-06-25 发布日期:2022-06-23
  • 通讯作者: 李杨欣，通信作者，研究方向：干细胞、外泌体、非编码RNA及炎症小体在心血管疾病中的作用。
  • 基金资助:
    国家自然科学基金重大研究计划项目(91849122)、国家自然科学基金面上项目(81870194)、江苏省“六大人才高峰”创新团队项目(BU24600117)

Research of DNA receptor AIM2 in cardiovascular diseases

LU Lin, WU Chengjie, TU Junchu, LI Yujie, ZHANG Yu, LI Yangxin   

  1. Institute for Cardiovascular Science and Department of Cardiovascular Surgery, First Affiliated Hospital and Medical College of Soochow University, Suzhou 215006, Jiangsu Province, China
  • Received:2022-04-14 Online:2022-06-25 Published:2022-06-23

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摘要： 黑色素瘤缺乏因子(absent in melanoma 2, AIM2)，是PYHIN(含pyrin和HIN结构域蛋白质)家族的一员，在感应双链DNA(dsDNA)和组装AIM2炎症小体方面发挥重要作用。AIM2炎症小体，具有促炎症和促焦亡特性，与心血管疾病的发生发展密切相关，可在动脉粥样硬化斑块、主动脉瘤壁和受损心肌中被激活，且激活受到多种因素的严格调控。文章总结了AIM2的最新研究进展，介绍不同因素对AIM2炎症小体激活的机制和作用。此外，还探讨了AIM2与动脉粥样硬化、主动脉瘤、心肌梗死和心力衰竭病理之间的相互影响，为更好地理解AIM2在心血管疾病中的病理作用、开发新治疗方法助力。

关键词: 黑色素瘤缺乏因子, 炎症小体, 心血管疾病

Abstract: Absent in Melanoma 2(AIM2), a member of the PYHIN(Containing Pyrin and HIN domain proteins) families, plays an important role in sensing dsDNA and assembling AIM2 inflammatory bodies. AIM2 inflammasome, with pro-inflammatory and pro-pyrolytic properties, is closely related to the occurrence and development of cardiovascular diseases. It can be activated in atherosclerotic plaques, aortic aneurysm walls and damaged myocardium, and its activation is strictly regulated by a variety of factors. We summarize the latest knowledge of AIM2 biology and provide new insights into the mechanisms and roles of different factors in AIM2 inflammasome activation. In addition, we explore the interaction between AIM2 and the pathology of atherosclerosis, aortic aneurysm, myocardial infarction, and heart failure. A better understanding of the pathological role of AIM2 in cardiovascular disease will facilitate the development of new therapies.

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