自然杂志 ›› 2022, Vol. 44 ›› Issue (5): 347-356.doi: 10.3969/j.issn.0253-9608.2022.02.010

• 专题综述 • 上一篇    下一篇

循环肿瘤细胞与肿瘤精准医学

张天然①②③ ，高正良①②，邓丹④   

  1. ①上海大学医学院 附属南通医院(南通第六人民医院) 老年病研究所，江苏 南通 226011；②同济大学医学院 附属上海市养志康复医院基础研究中心，上海 201619；③复旦大学 基础医学院，上海市重大传染病和生物安全研究院，上海 200032；④上海交通大学医学院 附属新华医院 皮肤科，上海 200092
  • 收稿日期:2021-12-01 出版日期:2022-10-25 发布日期:2022-05-05
  • 通讯作者: 高正亮，通信作者，研究方向：发育、干细胞生物学、再生医学及肿瘤精准医学。 邓丹，通信作者，研究方向：皮肤肿瘤的治疗与临床，脂肪干细胞与组织工程/再生医学。
  • 基金资助:
    国家自然科学基金面上项目(82173396)

Circulating tumor cells and tumor precision medicine

ZHANG Tianran①②③ ，GAO Zhengliang①② ，DENG dan④   

  1. ①Institute of Geriatrics, Affiliated Nantong Hospital of Shanghai University (The Sixth People's Hospital of Nantong), School of medicine, Shanghai University, Nantong 226011, Jiangsu Province, China; ②Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai 201619, China; ③Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China; ④Department of Dermatology, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
  • Received:2021-12-01 Online:2022-10-25 Published:2022-05-05

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摘要： 循环肿瘤细胞(circulating tumor cells, CTCs) 于1869年被发现和首次报道，但其临床意义尚未得到充分认识。最近20多年来，伴随生命医学研究和技术的快速进展，CTCs的生物学研究日益系统深入，在肿瘤精准和个体化医学中开始展示巨大的应用潜力。为此，文章首先介绍和综述CTCs的基本生物学，包括CTCs和CTC簇的产生、迁移散播、异质性及其与肿瘤进展和转移的关系，而后着重论述循环肿瘤细胞的分离、纯化方法学的原理、技术进展和流程，并综述分离纯化后的分子检测与分析，最后简述和展望CTCs相关技术在肿瘤精准与个体化医疗中的潜在应用。

关键词: 循环肿瘤细胞, 分离纯化, CTCs液体活检, 肿瘤精准医学

Abstract: Circulating tumor cells (CTCs) were first discovered in 1869 but the clinical significance was not well appreciated. Over the past two decades, with rapid progresses in their biology and related technologies CTCs have reemerged as a major biomedical advance with great promises in tumor precision medicine. In this article, we start with introducing CTCs, their related CTC clusters and biology—origination, dissemination through circulation, heterogeneity, and their roles in tumor progression and metastasis. We then continue to detail the technological advances with CTC isolation, purification and characterization based on its biology characteristics. In the end, we discuss the potential clinical applications of CTCs in tumor precision and/or personalized medicine.

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