自然杂志 ›› 2019, Vol. 41 ›› Issue (6): 414-422.doi: 10.3969/j.issn.0253-9608.2019.06.004

• 专题综述 • 上一篇    下一篇

被中饱私囊的脂肪——非酒精性脂肪性肝病

陈轶妍，陆炎   

  1. 复旦大学 附属中山医院内分泌代谢病科，上海 200032
  • 收稿日期:2019-10-26 出版日期:2019-12-20 发布日期:2019-12-20
  • 通讯作者: 陆炎，通信作者，研究方向：代谢性疾病的病理生理机制研究。

Fry in liver’s own grease: Non-alcoholic fatty liver disease

CHEN Yiyan, LU Yan   

  1. Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai 200032, China
  • Received:2019-10-26 Online:2019-12-20 Published:2019-12-20

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摘要： 随着生活方式的转变，非酒精性脂肪性肝病(non-alcoholic fatty liver disease, NAFLD)的患病率逐渐升高，已成为全世界最常见的肝病之一，但其危害程度没有受到足够的重视，目前也没有理想的治疗药物。文章简要阐述NAFLD的发病机制以及治疗的研究进展，以加深对其理解。

关键词: 非酒精性脂肪性肝病, 甘油三酯, 发病机制, 治疗

Abstract: Due to lifestyle changes, the prevalence of non-alcoholic fatty liver disease (NAFLD) has increased and thus become one of the most common chronic liver diseases globally. However, adverse outcomes of NAFLD are undervalued and the first licensed drug for NAFLD has not yet been approved. Here, we summarize recent progress in the studies of the mechanism and new therapies of NAFLD, which may provide a better understanding of this disease.

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