流感病毒VS流感疫苗—— 一场已经进行了百年的战争

自然杂志 ›› 2009, Vol. 31 ›› Issue (4): 207-.

流感病毒VS流感疫苗—— 一场已经进行了百年的战争

蔡一村①黄川②库志强③黄忠④

①②研究助理，④研究员，中国科学院上海巴斯德研究所，疫苗学与抗病毒策略研究组，上海 200025；③实习生，华中农业大学动物医学院，武汉 430071

收稿日期:2009-06-04 修回日期:2009-07-04 出版日期:2009-08-25 发布日期:2008-08-25

Influenza Virus VS Influenza Vaccine：A Nonstop War Over the Last One Hundred Years

CAI Yicun①，HUANG Chuan②，KU Zhiqiang③，HUANG Zhong④

①②RA, ④PI, Institut Pasteur of Shanghai , Vaccinology and Antiviral Strategies, Chinese Academy of Sciences, Shanghai 200025,China; ③Internship, college of veterinary medicine, HuaZhong Agriculture University, Wuhan 430071, China

Received:2009-06-04 Revised:2009-07-04 Online:2009-08-25 Published:2008-08-25

摘要/Abstract

摘要： 在过去的一百年中，发生了数次强致病性的流感大流行，每次数百万人死亡，时至今日流感病毒仍然对全球公共卫生构成了严重的威胁。2009年4月，甲型H1N1流感病毒最初现于墨西哥，目前已迅速蔓延到世界各大洲，严重威胁着人们的健康。接种疫苗已被证实是目前最为有效的防止病毒感染和传播的方法。但是，在疫苗技术不断升级的同时，我们不得不面对的是变异更为迅速的流感病毒。因此，新型流感病毒与新型抗流感病毒疫苗之间的战争从未停止，也不会停止。在这篇文章中，我们对一些流感病毒相关的基本但十分重要的知识进行了介绍，结合传统的和现代的流感疫苗技术进行了讨论。我们相信，通过采用先进的分子生物学工具（手段）和重组技术，高效的流感疫苗可以被迅速设计并制造，使我们具有足够的能力应对潜在的全球流感大流行。在这场对抗中，我们任重而道远。

关键词: 流行性感冒, 疫苗, 流感病毒, 甲型H1N1, H5N1

Abstract:
In the last one hundred years, several major influenza pandemics occurred, each of which resulted in millions of human deaths. Since this April, the A/H1N1 influenza virus that originally appeared in Mexico has quickly spread to other continents, posing a threat to the global population. Vaccination has been demonstrated to be the most effective way to prevent virus infection and transmission. However, influenza viruses keep mutating constantly. Thus, there is always a battle between newly emerging influenza viruses and the developed corresponding vaccines. In this article, some basic yet important knowledge regarding influenza virus is introduced, and traditional and modern approaches to influenza vaccines are discussed. It is believed that, by employing advanced molecular biology tools and recombinant production technologies, effective influenza vaccines can be rapidly designed and produced for global vaccination in response to potential pandemic threat.

Key words: influenza, vaccine, nfluenza virus, A/H1N1, H5N1

蔡一村黄川库志强黄忠. 流感病毒VS流感疫苗—— 一场已经进行了百年的战争[J]. 自然杂志, 2009, 31(4): 207-.

CAI Yi-Cun;HUANG Chuan;KU Zhi-Jiang;HUANG Zhong. Influenza Virus VS Influenza Vaccine：A Nonstop War Over the Last One Hundred Years[J]. Chinese Journal of Nature, 2009, 31(4): 207-.