自然杂志 ›› 2011, Vol. 33 ›› Issue (5): 271-274.doi: 10.3969/j.issn.0253-9608.2011.05.005

• 科技进展 • 上一篇    下一篇

奠基者基因的进化年龄及其意义

吕宝忠   

  1. 研究员，上海交通大学肿瘤研究所，上海 200032
  • 收稿日期:2011-05-12 修回日期:2011-06-12 出版日期:2011-10-25 发布日期:2011-10-25

Evolutionary Birth of Founder Genes for Macroevolution and Its Significance

Lyu Bao-zhong   

  1. Professor, Shanghai Cancer Institute,  Shanghai Jiaotong University, Shanghai 200032,  China  
  • Received:2011-05-12 Revised:2011-06-12 Online:2011-10-25 Published:2011-10-25

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摘要： 宏演化的趋势之一是生物由简单到复杂。传统上，这是古生物学、比较形态学和进化发育探讨的主题。随着基因组数据的不断积累，当今一支以基因组进化年龄层分析为主要研究方法的新军加入了进来。基因组进化年龄层就是在系统发育层面上新出现一组共同起源的奠基者基因。本文将介绍这支新军及其在个体发育和肿瘤研究上发挥的作用。

关键词: 奠基者基因, 宏演化, 系统发育年龄层, 个体发育, 癌基因

Abstract:

Traditionally, the macroevolutionary trends were explored by paleobiology, comparative morphology and evo-devo approaches. Recently, genomic phylostratigraphy, a new approach, has appeared on these trends, with the cumulative increase of genomic data. It can contribute to analyses for phylotypic stage in the relationship between phylogeny and ontogeny, as well as cancer studies. The paper presents the core of phylostratigraphy and its significance for ontogeny and cancer research.

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