氧感知机制的揭示有助于多种疾病的治疗 ——解读2019年诺贝尔生理学或医学奖

姜继宗

doi:10.3969/j.issn.0253-9608.2019.06.002

自然杂志 >

2019 , Vol. 41 >Issue 6: 401 - 406

DOI: https://doi.org/10.3969/j.issn.0253-9608.2019.06.002

诺贝尔奖简介

氧感知机制的揭示有助于多种疾病的治疗 ——解读2019年诺贝尔生理学或医学奖

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上海大学医学院(筹)，上海 200444

姜继宗，通信作者，研究方向：药物新剂型及体内过程。

收稿日期: 2019-10-25

网络出版日期: 2019-12-20

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The revealing of oxygen sensing mechanism is conductive to fighting many diseases: The interpretation of Nobel Prize in Physiology or Medicine 2019#br#

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The Medical School of Shanghai University (in preparation), Shanghai 200444, China

Received date: 2019-10-25

Online published: 2019-12-20

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摘要

细胞感知和适应氧气浓度变化是生命活动过程中最重要的机制之一。2019年诺贝尔生理学或医学奖颁发给致力于研究细胞感知及适应氧气机制的三位科学家，以表彰他们在阐明细胞氧感知通路方面的巨大贡献。文章阐述了三位科学家在细胞氧感知领域的研究成果及研究历程，并展望了其研究成果对治疗多种疾病的重要意义及深远影响。

关键词： 细胞; 氧感知; HIF-1a

本文引用格式

姜继宗 . 氧感知机制的揭示有助于多种疾病的治疗 ——解读2019年诺贝尔生理学或医学奖[J]. 自然杂志, 2019 , 41(6) : 401 -406 . DOI: 10.3969/j.issn.0253-9608.2019.06.002

Abstract

Cell sensing and adapting to changing oxygen concentration is one of life’s most essential adaptive processes. The Nobel Prize in Physiology or Medicine 2019 was awarded jointly to the three scientists who dedicated to studying cell sensing and adapting to changing oxygen availability because of their great contributions in revealing the cellular oxygen sensing pathway. This paper
elaborates the research results and research progress of the three scientists in the field of cell oxygen sensing, and looks forward to the significance and far-reaching impact of their research results on fighting various diseases.

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