干细胞引领生物医学革命

王勇, 杨静思, 韩兴龙, 胡士军, 殷为民, 雷伟

doi:10.3969/j.issn.0253-9608.2020.02.002

自然杂志 >

2020 , Vol. 42 >Issue 2: 84 - 90

DOI: https://doi.org/10.3969/j.issn.0253-9608.2020.02.002

专题综述

干细胞引领生物医学革命

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①苏州大学附属第一医院心脏大血管外科，江苏苏州 215000；②苏州大学医学部心血管病研究所，江苏苏州 215000

殷为民，通信作者，研究方向：动物分子遗传与基因工程。雷伟，通信作者，研究方向：干细胞与心血管疾病转化医学。

收稿日期: 2019-12-31

网络出版日期: 2020-04-18

基金资助

空间站工程航天医学实验项目(HYZHXM01018)；航天医学基础与应用国家重点实验室开放课题(SMFA17K02)

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Stem cells lead the biomedical revolution

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①Department of Cardiovascular Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China; ②Institute for Cardiovascular Science, Medical College, Soochow University, Suzhou 215000, Jiangsu Province, China

Received date: 2019-12-31

Online published: 2020-04-18

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摘要

干细胞是一类具有自我增殖能力和多向分化潜能的细胞。以胚胎干细胞和诱导多能干细胞为核心的干细胞技术的跨越
式发展正引领着一场新的生物医学革命。文章主要介绍干细胞技术的发展及其在细胞治疗、疾病模型、药物筛选和人造器
官等领域的研究进展与挑战。尽管干细胞基础研究取得了巨大进步，但是干细胞技术的临床转化和产业化仍然面临诸多挑
战。如何更好地利用干细胞和交叉学科新技术为人类服务还有很多事情等着我们去做。

关键词： 干细胞; 生物医学; 临床转化

本文引用格式

王勇, 杨静思, 韩兴龙, 胡士军, 殷为民, 雷伟 . 干细胞引领生物医学革命[J]. 自然杂志, 2020 , 42(2) : 84 -90 . DOI: 10.3969/j.issn.0253-9608.2020.02.002

Abstract

Stem cell is a kind of cells with self-proliferation ability and the potential of multi-directional differentiation. Advances in stem cell technologies, with embryonic stem cells and induced pluripotent stem cells as the core, are leading a biomedical revolution. This review mainly introduces the development of stem cell technologies, as well as their research progress and challenges in cell therapy, disease model, drug screening and organoids. Despite the great progress in basic stem cell research, the clinical transformation and industrialization of stem cell technologies still face many challenges. There is still much to be done to make better use of stem cells and cross-disciplinary technologies.

Key words： stem cell, biomedicine, clinical transformation

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