Sirt1是一种NAD+ 依赖性去乙酰化酶，其可将细胞的代谢状态直接与染色质结构和基因表达的调节耦合，进而影响多 种组织与器官的能量代谢，如调控肝脏糖脂质代谢、骨骼肌蛋白代谢、胰岛β细胞分泌胰岛素及其敏感性、脂肪组织分化以 及白色脂肪的褐色重塑、下丘脑中营养物质的利用等。然而，这些调控的紊乱与许多代谢性疾病的分子病理学密切相关，包 括肥胖和2型糖尿病。文章系统性地阐述Sirt1在机体能量代谢中的相关作用，旨在进一步为相关代谢疾病提供可能的治疗靶 点。

Sirt1 is an NAD+ -dependent deacetylase, which can directly couple the metabolic state of cells with the regulation of chromatin structure and gene expression, which in turn affects the energy metabolism of various tissues and organs, such as regulating liver glycolipid metabolism, skeletal muscle protein metabolism, secretion function of pancreatic islet β cells and insulin sensitivity, differentiation of adipose tissue and brown remodeling of white fat, utilization of nutrients in the hypothalamus. However, these regulatory disturbances and molecular pathology of many metabolic diseases are closely related, including obesity and type 2 diabetes. This article systematically elaborates the role of Sirt1 in the body’s energy metabolism, aiming to provide a possible therapeutic target for related metabolic diseases.