脂质体的制备是当今纳米材料和生物医学工程研究的一个重要领域,尤其在制备粒度可控、尺寸均匀、组分可调的脂质体方面还面临着较大的挑战。微混合器作为微流控技术中的重要组成部分之一,它可以通过微米级通道控制流体的混合,从而实现高效、精准、可控的脂质体制备。文章概述了脂质体的制备方法及微流控技术的优势,并介绍了不同类型的微混合器在脂质体制备中的应用及优缺点,重点对微混合器的流动机理进行了综述,旨在为微混合器在脂质体制备中的应用研究提供一定的参考。
The production of liposomes is an important field in the research of nanomaterials and biomedical engineering nowadays. Especially, the production of lipids with controllable particle size, uniform size and adjustable components still faces a significant challenge. Micromixers, as one of the important components of microfluidics, can control the mixing of fluids through micron-scale channels to achieve efficient, accurate and controllable liposome production. This review outlines the methods of liposome production and the advantages of microfluidics, and introduces the application, advantages and disadvantages of different types of micromixers in liposome production, focusing on the flow mechanisms of different types of micromixers, aiming to provide some reference for the study of the application of micromixers in liposome production.