射血分数保留型心力衰竭的病理机制及治疗

宋佳欣, 沈沭彤, 周秋莲, 高娟

doi:10.3969/j.issn.0253-9608.2023.04.016

自然杂志 >

2024 , Vol. 46 >Issue 4: 306 - 316

DOI: https://doi.org/10.3969/j.issn.0253-9608.2023.04.016

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射血分数保留型心力衰竭的病理机制及治疗

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①上海大学生命科学学院，上海器官修复工程技术研究中心，上海 200444；②复旦大学附属中山医院心内科，上海 200032；③上海大学医学院，上海器官修复工程技术研究中心，上海 200444

周秋莲，研究方向：心血管疾病机制研究。

高娟，研究方向：血小板功能调控和心血管病的发生机制。

收稿日期: 2023-01-26

网络出版日期: 2024-08-21

基金资助

国家自然科学基金项目(82170390，82200321，81900356)、上海市科委自然科学基金项目(21ZR1422700)

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Pathological mechanism and treatment methods of heart failure with preserved ejection fraction#br#

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① School of Life Science, Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China; ② Department of Cardiology, Zhongshan Hospital, Fudan University, Shanghai 200032, China; ③ School of Medicine, Shanghai Engineering Research Center of Organ Repair, Shanghai University, Shanghai 200444, China

Received date: 2023-01-26

Online published: 2024-08-21

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摘要

射血分数保留型心力衰竭(HFpEF)影响着全球一半左右的心力衰竭患者，其患病率随着人口老龄化呈逐年上升趋势，且具有较高的死亡率。然而，HFpEF的病理机制非常复杂，目前尚缺乏有效的治疗手段。结合近年来相关研究进展，文章阐述并讨论了HFpEF病理机制及现有治疗方法，以期为提高HFpEF患者的生活质量和改善患者的预后提供新思路。

关键词： 心力衰竭; 射血分数保留型心力衰竭; 病理机制; 治疗方法

本文引用格式

宋佳欣, 沈沭彤, 周秋莲, 高娟 . 射血分数保留型心力衰竭的病理机制及治疗[J]. 自然杂志, 2024 , 46(4) : 306 -316 . DOI: 10.3969/j.issn.0253-9608.2023.04.016

Abstract

Heart failure with preserved ejection fraction (HFpEF) affects about half of all patients with heart failure worldwide. The prevalence rate continues to grow with aging population year by year, while HFpEF has a high mortality rate. However, the pathogenesis of HFpEF is complex, and there is still lack of effective treatment. With the research progress in recent years, this review aims to elaborate and discuss the pathological mechanism of HFpEF and current treatment methods, providing an insight into developing novel therapeutic strategies for improving HFpEF.

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