2024年诺贝尔化学奖授予了在蛋白质结构设计与预测领域作出决定性贡献的三位科学家：大卫•贝克(David Baker)、德米斯•哈萨比斯(Demis Hassabis)和约翰•朱姆珀(John M. Jumper)。本文围绕三位获奖者，主要介绍了计算结构生物学领域中蛋白质设计与预测的科学背景、主要历史挑战，以及该科学突破的发展历程和对未来的影响。

The 2024 Nobel Prize in Chemistry was awarded to three scientists — David Baker, Demis Hassabis, and John M. Jumper — for their groundbreaking contributions to the design and prediction of protein structures. This article highlights their work, offering an overview of the scientific background behind protein design and prediction in computational structural biology, the key historical challenges in the field, and how this breakthrough evolved. It also explores the far-reaching implications of their achievements for the future.