运动介导miRNA促进心脏修复的微观机制与宏观效应

姜继宗, 王睿, 张欣欣, 肖俊杰

doi:10.3969/j.issn.0253-9608.2025.03.001

自然杂志 >

2025 , Vol. 47 >Issue 3: 157 - 163

DOI: https://doi.org/10.3969/j.issn.0253-9608.2025.03.001

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运动介导miRNA促进心脏修复的微观机制与宏观效应

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①上海大学医学院，上海 200444；②上海大学生命科学学院，上海 200444

肖俊杰，研究方向：心力衰竭的综合干预和风险预警策略。

收稿日期: 2025-04-01

网络出版日期: 2025-05-12

基金资助

上海市2022年度“科技创新行动计划”自然科学基金面上项目(22ZR1423100)

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Microscopic mechanism and macroscopic effects of exercise-mediated miRNA in facilitating cardiac repair

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① School of Medicine, Shanghai University, Shanghai 200444, China; ② School of Life Sciences, Shanghai University, Shanghai 200444, China

Received date: 2025-04-01

Online published: 2025-05-12

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摘要

2024年诺贝尔生理学或医学奖的颁发凸显了微小RNA(miRNA)在基因调控中的重要地位。规律运动作为心血管保护的 “天然处方”，可通过调控miRNA网络促进心脏修复。本文首先对miRNA进行介绍并总结了目前发现的一系列miRNA与心血管疾病之间的紧密联系，最后汇总了运动介导的miRNA在心脏修复中的多维调控机制与治疗潜力，为心血管疾病提供了非药物干预的新范式。

关键词： 微小RNA; 运动; 心血管疾病; 分子机制; 心脏修复

本文引用格式

姜继宗, 王睿, 张欣欣, 肖俊杰 . 运动介导miRNA促进心脏修复的微观机制与宏观效应[J]. 自然杂志, 2025 , 47(3) : 157 -163 . DOI: 10.3969/j.issn.0253-9608.2025.03.001

Abstract

The awarding of the 2024 Nobel Prize in Physiology or Medicine emphasizes the important role of microRNA (miRNA) in gene regulation. Regular exercise serves as a “natural prescription” for cardiovascular protection and promotes cardiac repair by regulating the miRNA network. In this review, we initially introduce miRNA and summarize the close connection between miRNA and cardiovascular diseases. Finally, we have summarized the multi-dimensional regulatory mechanism and therapeutic potential of exercise-mediated miRNA in cardiac repair, providing a new model for non-drug intervention in cardiovascular diseases.

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