诺贝尔奖简介

2015年诺贝尔化学奖钟情于基因组DNA"修理工"

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  • 首都师范大学生命科学学院DNA损伤应答北京市重点实验室,北京 100048
许兴智,首都师范大学特聘教授,研究方向:DNA损伤应答(肿瘤生物学)。

收稿日期: 2015-11-19

  网络出版日期: 2015-12-22

DNA-repair crew won the Nobel Prize in Chemistry 2015

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  • Beijing Key Laboratory of DNA Damage Response & College of Life Sciences, Capital Normal University, Beijing 100048, China

Received date: 2015-11-19

  Online published: 2015-12-22

摘要

 2015年诺贝尔化学奖授予了Tomas Lindahl、Paul Modrich和Aziz Sancar三位科学家,以表彰他们在“绘制细胞修 复损伤DNA和捍卫遗传信息(完整性)的机制研究”方面所做出的杰出贡献。简要介绍了三位获奖者的研究工作和成就, 以及DNA损伤修复与人类疾病(尤其是癌症)的发生、发展、诊断、治疗及预防的相关性。

本文引用格式

王静 彭斌 许兴智 . 2015年诺贝尔化学奖钟情于基因组DNA"修理工"[J]. 自然杂志, 2015 , 37(6) : 418 -423 . DOI: 10.3969/j.issn.0253-9608.2015.06.004

Abstract

 The Nobel Prize in Chemistry 2015 was awarded jointly to Tomas Lindahl, Paul Modrich and Aziz Sancar for having mapped and explained how the cell repairs its DNA and safeguards the genetic information. In this overview, we brie?y introduced  research achievements of the laureates and the link between DNA-repair and etiology, development, diagnosis, therapy, and the prevention of human diseases, cancer in particular.
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