Abstract: As a major geological event in the Earth’s history, the uplift of the Tibetan Plateau on the Asian climate and environment had a defining influence. During the past decades, many scholars from China and abroad have studied climatic and environmental effects of the plateau uplift by a variety of climate numerical models. These modeling studies have greatly deepened our understanding of mechanisms on the evolutions of Asian monsoon and Asian interior aridity. In recent researches on“plateau uplift- climate response”, an important progress is recognizing that there exists a close relationship between the Asian regional climate response and the form of the Tibetan Plateau uplift. This paper conducts a general introduction, focusing on a comprehensive analysis of a series
of sub-regional uplift simulations. It is pointed that the uplift of the northern Tibetan Plateau produced significant impacts on the evolution of the East Asian monsoon and Asian inland arid climates, with northward shifts of East Asian summer monsoon circulation and rainfall, and expansions or enhancements in arid regions, atmospheric dust loading and sedimentary areas as the most prominent features. A great deal of enlightenment is gained from these modeling results for the paleo-environmental researches of East Asia and thus many new scientific questions are raised.