Abstract: The 2010 Nobel Prize in Physiology or Medicine was awarded to Robert G. Edwards, regarded as “the father of Test Tube Baby”. The Test Tube Baby, known as a marvelous assisted reproductive technology, has brought significant influence into human society. Test Tube Baby was a technique merging in vitro fertilization and embryo transfer to help the infertile couples have descendants. The intracytoplasmic sperm injection (ICSI) and preimplantation genetic diagnosis (PGD) were the development and extension result of Test Tube Baby. In this essay, a brief introduction to the history，application and ethical issues of Test Tube Baby were given.

Key words: Robert G. Edwards, Test Tube Baby, in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI) , preimplantation genetic diagnosis (PGD),  haze/fog, PM_2.5, health