黏连蛋白维持基因组结构分子机制研究进展

doi:10.3969/j.issn.0253-9608.2020.00.003

摘要/Abstract

摘要： 黏连蛋白复合物在基因组维持中发挥重要功能。在细胞分裂期，黏连蛋白介导姐妹染色单体黏连，并对染色单体的正确分离起着决定性作用。近年来的研究表明，黏连蛋白维持哺乳动物细胞周期间期的三维基因组构象，决定了染色质环和拓扑关联结构域的形成。最近的生物物理学和结构生物学研究阐释了黏连蛋白装载DNA的分子机制，并证实了黏连蛋白具有挤压DNA环的功能。

关键词: 黏连蛋白, 姐妹染色体黏连, 基因组组织, 基因组维持, 拓扑关联结构域, 环挤压模型

Abstract: Cohesin is a key player in genome maintenance. During mitosis, cohesin mediates sister chromatid cohesion and plays an essential role in chromosome segregation. Recent research discovered that cohesin also organizes the 3D genome during interphase and is crucial for the formation of chromatin loops and topologically associating domains (TADs) in mammalian cells. The latest biophysical and structural studies have provided insights into the underlying mechanisms by which cohesin is loaded onto DNA and extrudes DNA loops.

史竹兵, 白晓辰, 于洪涛. 黏连蛋白维持基因组结构分子机制研究进展[J]. 自然杂志, 2021, 43(1): 1-8.

SHI Zhubing, BAI Xiaochen, YU Hongtao. Molecular insights into mechanisms of cohesin in genome maintenance[J]. Chinese Journal of Nature, 2021, 43(1): 1-8.

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