自然杂志 ›› 2020, Vol. 42 ›› Issue (6): 471-474.doi: 10.3969/j.issn.0253-9608.2020.06.006

• 专题综述 • 上一篇    下一篇

抗增殖蛋白2在帕金森病发病线粒体机制中的作用

张泰瑜，冯红   

  1. 天津体育学院 天津市运动生理与运动医学重点实验室，天津 300381
  • 收稿日期:2020-02-05 出版日期:2020-12-25 发布日期:2020-12-18
  • 通讯作者: 冯红，通信作者，研究方向：线粒体能量代谢调控。

Influence of prohibitin 2 in mitochondrial mechanism of Parkinson’s disease

ZHANG Taiyu, FENG Hong   

  1. Institute of Sports and Health, Tianjin University of Sport, Tianjin 300381, China
  • Received:2020-02-05 Online:2020-12-25 Published:2020-12-18

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摘要： 帕金森病是第二大神经退行性疾病，目前发病机制尚不明确且无法治愈。抗增殖蛋白2参与维持线粒体形态和功能的稳定、凋亡等多种生物学进程。文章主要阐述抗增殖蛋白2与帕金森病之间的联系，进而探讨抗增殖蛋白2在帕金森病发病 线粒体机制中的作用。

关键词: 抗增殖蛋白2, 帕金森病, 线粒体机制

Abstract: Parkinson’s disease, the second largest neurodegenerative disease, cannot be cured. Its pathogenesis is currently unclear. Prohibitin 2 participates in various biological processes such as apoptosis and maintaining the stability of mitochondrial morphology and function. The present review focuses on the relationship between prohibitin 2 and Parkinson’s disease, and then explores the role of prohibitin 2 in the mechanism of mitochondria in the pathogenesis of Parkinson’s disease.  

Key words:  , prohibitin 2, Parkinson’s disease, mitochondrial mechanism

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