新型冠状病毒重要药物靶标结构生物学及药物抑制机制研究

doi:10.3969/j.issn.0253-9608.2021.05.004

自然杂志 ›› 2021, Vol. 43 ›› Issue (5): 343-348.doi: 10.3969/j.issn.0253-9608.2021.05.004

新型冠状病毒重要药物靶标结构生物学及药物抑制机制研究

高海龙^①②，王镐锋^①②，赵耀^①② ，高岩^①②，王权^①②

①上海科技大学免疫化学研究所，上海 201210；②上海科技大学生命科学与技术学院，上海 201210

收稿日期:2021-07-20 出版日期:2021-10-22 发布日期:2021-10-22
作者简介:高海龙，通信作者，研究方向：生物大分子结构与功能研究。

Study of structural biology and inhibition mechanisms of important drug targets of SARS-CoV-2

GAO Hailong^①② , WANG Haofeng^①② , ZHAO Yao^①②, GAO Yan^①② , WANG Quan^①②

①Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China; ②School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China

Received:2021-07-20 Online:2021-10-22 Published:2021-10-22

摘要/Abstract

摘要： 迄今为止，新冠病毒肺炎疫情已造成全球近2亿人感染，数百万人因新冠肺炎而罹难。针对疫情病原——新型冠状病毒，人们对其重要药物靶标开展了深入而详实的研究。对药物靶标蛋白三维结构的解析，对于我们了解药物作用机制，以及开发新的药物具有非常重要的指导意义。文章总结了针对新冠病毒主蛋白酶及转录复制复合体的多种结构，分析了药物小分子抑制相应靶标蛋白的机制，以及对于抗击新冠疫情的重要意义。

关键词: 新型冠状病毒, 主蛋白酶, 转录复制复合体, 结构生物学, 药物筛选与开发

Abstract: So far, more than 200 million people were infected and millions of people have died during this worldwide COVID-19 pandemic. In response to the SARS-CoV-2, the pathogen of the epidemic, scientists have carried out in-depth and detailed researches on its drug targets. The analysis of the three-dimensional structures of drug target proteins has guiding significance for people to understand the mechanism of drug candidates and develop new drugs. This article summarizes the structures of the main protease and transcription-replication complex of SARS-CoV-2, analyzes the mechanism of small molecules inhibiting the corresponding target protein, and elucidates the significance in fighting the COVID-19 pandemic.

高海龙, 王镐锋, 赵耀, 高岩, 王权. 新型冠状病毒重要药物靶标结构生物学及药物抑制机制研究[J]. 自然杂志, 2021, 43(5): 343-348.

GAO Hailong , WANG Haofeng , ZHAO Yao , GAO Yan , WANG Quan. Study of structural biology and inhibition mechanisms of important drug targets of SARS-CoV-2[J]. Chinese Journal of Nature, 2021, 43(5): 343-348.

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新型冠状病毒重要药物靶标结构生物学及药物抑制机制研究

Study of structural biology and inhibition mechanisms of important drug targets of SARS-CoV-2

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