自然杂志 ›› 2021, Vol. 43 ›› Issue (1): 18-24.doi: 10.3969/j.issn.0253-9608.2021.01.003
刘凯雯,刘志杰,华甜
收稿日期:
2021-10-01
出版日期:
2021-02-25
发布日期:
2021-02-25
通讯作者:
刘志杰,通信作者,研究方向:结构生物学。
华甜,通信作者,研究方向:结构生物学。
LIU Kaiwen, LIU Zhijie, HUA Tian
Received:
2021-10-01
Online:
2021-02-25
Published:
2021-02-25
摘要: 趋化因子(chemokine)及趋化因子受体(chemokine receptor)在介导细胞迁移、增殖和抵御病原体入侵过程中发挥重要作用,并且与免疫环境中炎症和癌症的发生发展密切相关。人体中有20多种趋化因子受体和近50种趋化因子。一种趋化因子可以结合多种受体,反之亦然,它们相互作用构成了复杂的趋化因子调控网络。对趋化因子及其受体的三维结构的解析,对于我们更深入理解趋化因子受体家族的激活机制与药理功能具有非常重要的意义。文章总结了已解析的与内 源性趋化因子配体或其类似物结合的趋化因子受体结构,分析了趋化因子激活相应趋化因子受体的分子机制,以及对于抗 癌药物开发设计的重要性。
刘凯雯, 刘志杰, 华甜. 趋化因子受体的结构与信号转导机制[J]. 自然杂志, 2021, 43(1): 18-24.
LIU Kaiwen, LIU Zhijie, HUA Tian. Structural and signaling mechanism of chemokine receptors[J]. Chinese Journal of Nature, 2021, 43(1): 18-24.
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