自然杂志 ›› 2021, Vol. 43 ›› Issue (1): 45-52.doi: 10.3969/j.issn.0253-9608.2021.01.007
周庆同①,戴之卓②③,赵素文②③
收稿日期:
2020-10-01
出版日期:
2021-02-25
发布日期:
2021-02-25
通讯作者:
赵素文,通信作者,研究方向:蛋白质序列-结构-功能关系的计算生物学。
ZHOU Qingtong①, DAI Zhizhuo②③, ZHAO Suwen②③
Received:
2020-10-01
Online:
2021-02-25
Published:
2021-02-25
摘要: G蛋白偶联受体(G protein-coupled receptor, GPCR)构成人体中最庞大的膜蛋白家族,也是最重要的一类药物靶 标。随着GPCR结构解析技术的突破,目前已破解八十余个受体的400多个结构,揭示出GPCR复杂多样的配体结合模式和 跨膜信号转导机制。近年来,残基相互作用计算已实现对GPCR构象变化的精细描述,揭示出A家族GPCR存在共同的激活 机制。文章简要回顾GPCR激活机制研究的方法和创新点,并对A家族GPCR共同激活机制如何推动功能研究和药物研发进行展望。
周庆同, 戴之卓, 赵素文. G蛋白偶联受体的共同激活机制[J]. 自然杂志, 2021, 43(1): 45-52.
ZHOU Qingtong, DAI Zhizhuo, ZHAO Suwen. Common activation mechanism of GPCR[J]. Chinese Journal of Nature, 2021, 43(1): 45-52.
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