长链非编码RNA在癌症中的研究进展

摘要/Abstract

摘要： 长链非编码RNA(long noncoding RNA, lncRNA)是一类转录本长度超过200个核苷酸的非编码RNA，通常不编码蛋白质。随着研究的进展，人们发现lncRNA来源复杂、功能各异，在表观遗传学、转录水平、转录后水平等多个水平发挥着重要的作用。笔者旨在介绍lncRNA的来源及生物学功能，并着重阐述其在癌症生物学中的研究进展。

关键词: lncRNA, 癌症, 转录后调控

Abstract: Long noncoding RNA (lncRNA) is defined as transcripts longer than 200 nucleotides (nt) with little or no protein-coding capacity. It was found that lncRNA was originated in complicated sources, and played different functions in multiple levels such as epigenetic, transcriptional and post-transcriptional regulation levels. Here we briefly summarize the origin and biological function of lncRNA, and emphatically focus on the progress in cancer biology.

李艳利张诗梦汪菊金由辛. 长链非编码RNA在癌症中的研究进展[J]. 自然杂志, 2014, 36(3): 192-201.

LI Yan-Li;ZHANG Shi-Meng;HONG Ju;JIN Yao-Xin. Progress of long noncoding RNA in cancer[J]. Chinese Journal of Nature, 2014, 36(3): 192-201.

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