自然杂志 ›› 2020, Vol. 42 ›› Issue (6): 449-455.

• 诺贝尔奖简介 • 上一篇    下一篇

分子生物学技术推进丙型肝炎病毒的发现和研究 ——2020年诺贝尔生理学或医学奖解读

李庆超①，钟劲②   

  1. ①山东师范大学，济南 250000；②中国科学院上海巴斯德研究所，上海 200031
  • 收稿日期:2020-11-16 出版日期:2020-12-25 发布日期:2020-12-18
  • 通讯作者: 钟劲，通信作者，研究方向：分子病毒学及免疫学。

Molecular biology technology promotes hepatitis C virus discovery and research: The thoughts of Nobel Prize in Physiology or Medicine 2020

LI Qingchao①, ZHONG Jin②   

  1. ①Shandong Normal University, Ji'nan 250000, China; ②Institut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai 200031, China
  • Received:2020-11-16 Online:2020-12-25 Published:2020-12-18

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摘要： 在全球范围内估计有7100万丙型肝炎病毒感染者，其中相当多的患者会发展为肝硬化或肝癌，因此丙型肝炎病毒对人类健康造成重大威胁。2020年诺贝尔生理学或医学奖授予哈维•阿尔特、迈克尔•霍顿和查尔斯•赖斯，以表彰他们在“发现丙型肝炎病毒”工作中的卓越贡献。丙型肝炎病毒的研究历程无疑是人类与病毒斗争的胜利历史。从最初病毒的发现到抗病毒药物的成功研发，分子生物学技术的应用都发挥了关键的作用，为现代病毒学研究树立了典范。

关键词: 肝炎, 丙型肝炎病毒, 基因克隆, 细胞培养模型

Abstract:  A total of 71 million people in the world are estimated to have been infected by hepatitis C virus (HCV), and many of them are subject to develop liver cirrhosis or liver cancer. The Nobel Prize in Physiology or Medicine 2020 was awarded to Harvey J. Alter, Michael Houghton and Charles M. Rice for their outstanding contributions in “the discovery of hepatitis C virus”. The process of HCV research is no doubt a history of mankind’s victory in fighting against viruses. The application of molecular biology technology has played an instrumental role in many aspects, from the discovery of HCV to the successful development of antiviral drugs, which sets an excellent model for modern virology research. 

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