温度与触觉感受器的发现与研究进展——2021年诺贝尔生理学或医学奖解读

doi:10.3969/j.issn.0253-9608.2021.06.007

摘要/Abstract

摘要： 2021年诺贝尔生理学或医学奖授予戴维·朱利叶斯(David Jay Julius)和阿登·帕塔普蒂安(Ardem Patapoutian)，以表彰他们在发现温度与触觉感受器方面的贡献。文章回顾了两位科学家发现温度受体TRPV1和触觉受体PIEZO的历程，并介绍了这些受体自被发现以来的研究进展以及药物研发的巨大潜力。

关键词: TRPV1, PIEZO, 温度受体, 机械力受体

Abstract: The 2021 Nobel Prize in Physiology or Medicine is awarded to David Jay Julius and Ardem Patapoutian for their contributions to the discovery of temperature and touch receptors. We review the discovery of the temperature receptor TRPV1 and the touch receptor PIEZOs by the two scientists, and describe the research advance on these receptors and the great potential for drug discovery

解恒昌, 付小雨, 沈伟. 温度与触觉感受器的发现与研究进展——2021年诺贝尔生理学或医学奖解读[J]. 自然杂志, 2021, 43(6): 451-458.

XIE Hengchang, FU Xiaoyu, SHEN Wei. Discovery and research advance of temperature and touch receptors:Understanding of the 2021 Nobel Prize in Physiology or Medicine[J]. Chinese Journal of Nature, 2021, 43(6): 451-458.

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